Comparison of developmental outcomes in children with permanent and transient congenital hypothyroidism

Basit Öğe Kaydı
dc.authoridBuyukavci, Mehmet Akif/0000-0001-6884-1832
dc.authoridDundar, Ismail/0000-0003-1468-6405
dc.authorwosidBuyukavci, Mehmet Akif/HCH-2615-2022
dc.authorwosidDundar, Ismail/ABG-2027-2021
dc.contributor.authorBuyukavci, Mehmet Akif
dc.contributor.authorDundar, Ismail
dc.date.accessioned2024-08-04T20:53:36Z
dc.date.available2024-08-04T20:53:36Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives: Congenital hypothyroidism (CH) is still one of the most common causes of preventable cognitive impairment in children, and its early detection and treatment prevent irreversible neurodevelopmental delay. Depending on the underlying cause, cases with CH may be transient or permanent. This study aimed to compare the developmental evaluation results of transient and permanent CH patients and to reveal any differences.Methods: A total of 118 patients with CH, who were followed up jointly in pediatric endocrinology and developmental pediatrics clinics, were included. The patients' progress was evaluated per the International Guide for Monitoring Child Development (GMCD).Results: Of the cases, 52 (44.1%) were female, and 66 (55.9%) were male. While 20 (16.9%) cases were diagnosed with permanent CH, 98 (83.1%) were diagnosed with transient CH. According to the results of the developmental evaluation made with GMCD, the development of 101 (85.6%) children was compatible with their age, while 17 (14.4%) children had delays in at least one developmental area. All 17 patients had a delay in expressive language. Developmental delay was detected in 13 (13.3%) of those with transient CH and 4 (20%) with permanent CH.Conclusions: There is difficulty in expressive language in all cases of CH with developmental delay. No significant difference was found between the developmental evaluations of permanent and transient CH cases. The results revealed the importance of developmental follow-up, early diagnosis and interventions in those children. GMCD is thought to be an important guide to help monitoring the development of patients with CH.en_US
dc.identifier.doi10.1515/jpem-2022-0539
dc.identifier.endpage370en_US
dc.identifier.issn0334-018X
dc.identifier.issn2191-0251
dc.identifier.issue4en_US
dc.identifier.pmid36794655en_US
dc.identifier.scopus2-s2.0-85152165514en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage364en_US
dc.identifier.urihttps://doi.org/10.1515/jpem-2022-0539
dc.identifier.urihttps://hdl.handle.net/11616/101285
dc.identifier.volume36en_US
dc.identifier.wosWOS:000934125800001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWalter De Gruyter Gmbhen_US
dc.relation.ispartofJournal of Pediatric Endocrinology & Metabolismen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcongenital hypothyroidismen_US
dc.subjectdevelopmental delayen_US
dc.subjectlanguage developmenten_US
dc.titleComparison of developmental outcomes in children with permanent and transient congenital hypothyroidismen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu