The Protective Effects of Glycyrrhetinic Acid and Chrysin against Ischemia-Reperfusion Injury in Rat Ovaries

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dc.authoridbasak, nese/0000-0001-5566-8321
dc.authoridMELEKOGLU, RAUF/0000-0001-7113-6691
dc.authoridAlan, Saadet/0000-0003-2329-151X
dc.authorwosidbasak, nese/ABH-5495-2020
dc.authorwosidMELEKOGLU, RAUF/AAF-1614-2019
dc.authorwosidAlan, Saadet/ABH-4282-2020
dc.contributor.authorMelekoglu, Rauf
dc.contributor.authorCiftci, Osman
dc.contributor.authorEraslan, Sevil
dc.contributor.authorAlan, Saadet
dc.contributor.authorBasak, Nese
dc.date.accessioned2024-08-04T20:44:34Z
dc.date.available2024-08-04T20:44:34Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective. To evaluate the protective effects of glycyrrhetinic acid (GA) and chrysin (CH) on experimental ischemia-reperfusion (I/R) injury in rat ovaries using tissue oxidative stress marker levels, hormone levels, and histopathological scores. Methods. Sixty healthy rats were randomly divided into six equal groups: control, I/R, I/R + CH (50 mg/kg/day), I/R + GA (100 mg/kg/day), CH (50 mg/kg/day), and GA (100 mg/kg/day). Biochemical, hormonal, and histopathological evaluations were performed on blood and tissue samples 14 days after CH and GA treatment. Results. The antioxidant defense system parameters were significantly higher in the ovarian tissues of the I/R + CH and I/R + GA groups than in those of the I/R group. Serum follicle-stimulating hormone levels were significantly reduced, and serum anti-Mullerian hormone levels were significantly increased in rats treated with CH and GA compared with those in the I/R group. Additionally, the histopathological scores of the I/R + CH and I/R + GA groups were significantly improved compared with those of the I/R group. Conclusions. The significant improvements in tissue oxidative stress parameters, serum hormone levels, and histological scores observed in this study indicate that treatment with CH or GA may be a conservative approach to prevent I/R injury in adnexal torsion cases after the ovarian detorsion procedure.en_US
dc.description.sponsorshipResearch Fund of Inonu University [2016/62]en_US
dc.description.sponsorshipThis research was supported by the Research Fund of Inonu University (Project no. 2016/62).en_US
dc.identifier.doi10.1155/2018/5421308
dc.identifier.issn2314-6133
dc.identifier.issn2314-6141
dc.identifier.pmid29862276en_US
dc.identifier.scopus2-s2.0-85047875490en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1155/2018/5421308
dc.identifier.urihttps://hdl.handle.net/11616/98311
dc.identifier.volume2018en_US
dc.identifier.wosWOS:000431921700001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHindawi Ltden_US
dc.relation.ispartofBiomed Research Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIschemia/Reperfusion Injuryen_US
dc.subjectCerebral Ischemia/Reperfusionen_US
dc.subjectOxidative Stressen_US
dc.subjectTorsionen_US
dc.subjectDamageen_US
dc.subjectTissueen_US
dc.subjectAssayen_US
dc.titleThe Protective Effects of Glycyrrhetinic Acid and Chrysin against Ischemia-Reperfusion Injury in Rat Ovariesen_US
dc.typeArticleen_US

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