Experimental otoacoustic emission and auditory brainstem response changes by stellate ganglion blockage in rat

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dc.authoridKIZILAY, Ahmet/0000-0003-3048-6489
dc.authoridOZTURAN, ORHAN/0000-0002-6129-8627
dc.authoridyucel ekici, nur/0000-0001-5074-4575
dc.authorwosidOZTURAN, ORHAN/E-9610-2012
dc.authorwosidKIZILAY, Ahmet/ABI-8293-2020
dc.authorwosidOZTURAN, ORHAN/B-4984-2015
dc.contributor.authorFirat, Yezdan
dc.contributor.authorKizilay, Ahmet
dc.contributor.authorOzturan, Orhan
dc.contributor.authorEkici, Nur
dc.date.accessioned2024-08-04T20:30:57Z
dc.date.available2024-08-04T20:30:57Z
dc.date.issued2008
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIntroduction: To investigate the effect of stellate ganglion (SG) block on hearing in rats. Materials and methods: Sixteen male adult rats were randomly divided into 2 equal groups. Both groups underwent preblock auditory brainstem responses (ABRs) in response to tone bursts at 4, 6, and 8 kHz and otoacoustic emissions in response to distortion products as a function of f2 frequency at 1, 2, 4, and 6 kHz. Local anesthetic (0.2 mL of 2% prilokain) was administered to the left SG of the study group by posterior cervical percutaneous approach for cervical sympathetic blockage. In the control group, 0.2 mL of physiological saline was injected to the left SG. Postblock hearing evaluations were made after 15 minutes of injections. Results: Both Dp-gram and I/O function records suggested that whereas hearing thresholds were not affected in lower frequencies after SG blockage, it tended to increase at higher frequencies. In ABR records, waves I and II showed marked latency shift across all frequencies. The interpeak latency of waves I and II was shortened after blockage. Saline injection did not show any significant ABR or distortion-product otoacoustic emission threshold shift across frequencies at 60, 70, 80, and 90 dB sound pressure level. Conclusion: Our data demonstrate that SG block improved the hearing parameters in rats with normal cochlear blood flow. To recommend SG blockage as a treatment option in the vascular pathologies of cochlea, further investigation should assess the efficiency of ganglion blockage in hearing parameters of rats with impaired cochlear blood flow. (C) 2008 Elsevier Inc. All rights reserved.en_US
dc.description.sponsorshipInonu University [2005/17-TIP]en_US
dc.description.sponsorshipThis research was supported by a research fund of our university, Inonu University, Unit of Scientific Research Projects (2005/17-TIP). The authors also gratefully acknowledge the statistical assistance of Saint Yologlu.en_US
dc.identifier.doi10.1016/j.amjoto.2008.02.001
dc.identifier.endpage345en_US
dc.identifier.issn0196-0709
dc.identifier.issn1532-818X
dc.identifier.issue5en_US
dc.identifier.pmid18722891en_US
dc.identifier.scopus2-s2.0-49649103979en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage339en_US
dc.identifier.urihttps://doi.org/10.1016/j.amjoto.2008.02.001
dc.identifier.urihttps://hdl.handle.net/11616/94624
dc.identifier.volume29en_US
dc.identifier.wosWOS:000259112100008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherW B Saunders Co-Elsevier Incen_US
dc.relation.ispartofAmerican Journal of Otolaryngologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCochlear Blood-Flowen_US
dc.subjectHearing-Lossen_US
dc.subjectIschemiaen_US
dc.subjectInnervationen_US
dc.subjectCisplatinen_US
dc.titleExperimental otoacoustic emission and auditory brainstem response changes by stellate ganglion blockage in raten_US
dc.typeArticleen_US

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