Sarcopenia and clinical presentation
Küçük Resim Yok
Tarih
2017
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Sarcopenia is characterized by the progressive generalized loss of muscle function, quality, strength and mass. Although it is known as a primary geriatric disease, it may also develop in younger individuals secondary to immobilization, malnutrion and cachexia The exact etiology is unknown, but the most commonly suggested contributory factors are a decrease in protein synthesis,mitochondrial dysfunction, reactive oxygen products, chronic inflammation, nutritional deficiency, loss of perfusion, age-relatedneuromuscular alterations, decrease in sex hormone, growth hormone (GH), insulin-like growth factor (IGF-1) and vitamin D levelstogether with physical inactivity.There are severe negative effects on quality of life and the individual's socio-economic status and thus, sarcopenia is a significantpublic health problem. Sarcopenia is strongly correlated with the increased fragility that develops in the elderly and is a significantrisk factor and also an indicator of disability and mortality.The evaluation of muscle strength and physical performance is mandatory for the diagnosis of sarcopenia. Despite the lack of adefinitive treatment method, the most commonly accepted approaches include physical activity, nutritional supplementationtherapy, and hormonal and new pharmacological agents.In this review sarcopenia, which is a common but sometimes misdiagnosed condition in clinical practice, is discussed in the light of current knowledge.
Açıklama
Anahtar Kelimeler
Kaynak
Turgut Özal Tıp Merkezi Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
24
Sayı
1
