Effect of fish oil supplementation on plasma oxidant/antioxidant status in rats

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dc.authoridOzgocmen, Salih/0000-0002-4860-452X
dc.authoridOzgocmen, Salih/0000-0002-4860-452X;
dc.authorwosidOzgocmen, Salih/K-9588-2015
dc.authorwosidOzgocmen, Salih/K-4680-2019
dc.authorwosidFadillioglu, Ersin/K-3817-2019
dc.authorwosidErdogan, Hasan/AFN-9249-2022
dc.contributor.authorErdogan, H
dc.contributor.authorFadillioglu, E
dc.contributor.authorOzgocmen, S
dc.contributor.authorSogut, S
dc.contributor.authorOzyurt, B
dc.contributor.authorAkyol, O
dc.contributor.authorArdicoglu, O
dc.date.accessioned2024-08-04T20:15:13Z
dc.date.available2024-08-04T20:15:13Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate effect of dietary omega-3 fatty acid supplementation on the indices of in vivo lipid peroxidation and oxidant/antioxidant status of plasma in rats. The plasma thiobarbituric acid reactive substances (TBARS) and nitric oxide (NO) levels, and activities of xanthine oxidase (XO), superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) were studied in male Wistar Albino rats after ingestion of 0.4 g/ kg fish oil (rich in omega-3 fatty acids, eicosapentaenoic acid and docosahexaenoic acid) for 30 days and compared to untreated control rats. The rats in the treated group had significantly higher SOD activity (P < 0.001), NO levels (P < 0.01) and decreased TBARS levels (P < 0.05) with respect to controls whereas GSH-Px and XO activities were not significantly different between the groups. None of the measured parameters had significant correlation with each other in both groups. We conclude that dietary supplementation of omega-3 fatty acids may enhance resistance to free radical attack and reduce lipid peroxidation. These results support the notion that omega-3 fatty acids may be effective dietary supplements in the management of various diseases in which oxidant/antioxidant defence mechanisms are decelerated. (C) 2004 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.plefa.2004.02.001
dc.identifier.endpage152en_US
dc.identifier.issn0952-3278
dc.identifier.issue3en_US
dc.identifier.pmid15253883en_US
dc.identifier.scopus2-s2.0-3142608825en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage149en_US
dc.identifier.urihttps://doi.org/10.1016/j.plefa.2004.02.001
dc.identifier.urihttps://hdl.handle.net/11616/94245
dc.identifier.volume71en_US
dc.identifier.wosWOS:000223001600003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherChurchill Livingstoneen_US
dc.relation.ispartofProstaglandins Leukotrienes and Essential Fatty Acidsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcid Phenethyl Esteren_US
dc.subjectN-3 Fatty-Acidsen_US
dc.subjectLipid-Peroxidationen_US
dc.subjectAlpha-Tocopherolen_US
dc.subjectEicosapentaenoic Aciden_US
dc.subjectDocosahexaenoic Aciden_US
dc.subjectPostmenopausal Womenen_US
dc.subjectRheumatoid-Arthritisen_US
dc.subjectAntioxidant Statusen_US
dc.subjectOmega-3-Fatty-Acidsen_US
dc.titleEffect of fish oil supplementation on plasma oxidant/antioxidant status in ratsen_US
dc.typeArticleen_US

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