Evaluation of right ventricular function in patients with Behcet's disease by four-dimensional echocardiography

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dc.contributor.authorUlutas, Zeynep
dc.contributor.authorTasolar, Hakan
dc.contributor.authorKaraagac, Mirac
dc.contributor.authorHidayet, Siho
dc.contributor.authorKaraca, Yucel
dc.contributor.authorBayramoglu, Adil
dc.contributor.authorYolbas, Servet
dc.date.accessioned2026-04-04T13:33:22Z
dc.date.available2026-04-04T13:33:22Z
dc.date.issued2024
dc.departmentİnönü Üniversitesi
dc.description.abstractAimBehcet's disease (BD) is a systemic disorder characterized by vasculitis, resulting in thickened vascular walls that reduce elasticity and impair function. BD can involve the cardiovascular system in three ways: cardiac, arterial, and venous. In this study, our objective was to evaluate the efficacy of pulmonary arterial stiffness (PAS) and pulmonary pulse transit time (PPTT) measures in demonstrating right ventricular functions in asymptomatic BD patients. We aimed to objectively evaluate right ventricular function in patients with BD using four-dimensional echocardiography (4DE).MethodThis study included 40 patients diagnosed with BD and 40 healthy subjects. Demographic, clinical, laboratory, and echocardiographic parameters were compared. In addition to standard transthoracic echocardiographic evaluation, right ventricle quantification (RVQ) by using the 4DE and 2D-speckle tracking echocardiography were performed.ResultsThe sPAP, 4D RVQ, and right ventricular strain values exhibited significant differences between the BD and control groups. Right ventricular end-diastolic diameter (RVDD), right ventricular end-systolic diameter (RVSD), right atrium (RA) area, right ventricular myocardial performance index (RVMPI), and PAS were increased in BD patients compared to the control group. Right ventricular ejection fraction (RVEF), right ventricular fractional area change (RVFAC), tricuspid annular plane systolic excursion (TAPSE), Tricuspid S', and PPTT were decreased in BD patients compared to control subjects. PPTT correlated with right ventricular free wall strain (RV-FWS) and PAS. In a multivariate linear regression analysis, PAS and RVFAC were found to be independent predictors of RVFWS. In addition, RVFAC and TAPSE are independent predictors for PPTT.ConclusionPatients with BD may have elevated pulmonary arterial stiffness (PAS) in correlation with decreased PPTT. To ascertain the prognosis for these individuals, right ventricular (RV) functions must be evaluated. Measurements of RVFAC and RVEF via 4DE and deformation imaging techniques may be more useful in identifying subclinical impairment of RV. Individuals with BD, PAS, and PPTT may suggest a link between early pulmonary vascular remodeling and RV subclinical impairment. Four-dimensional transthoracic echocardiography evaluation of right ventricular function allows more detailed and comprehensive imaging in BD patients. image
dc.description.sponsorshipThe authors did not receive any financial support for this article.
dc.identifier.doi10.1111/echo.15918
dc.identifier.issn0742-2822
dc.identifier.issn1540-8175
dc.identifier.issue9
dc.identifier.orcid0000-0002-4103-9345
dc.identifier.orcid0000-0002-5688-6977
dc.identifier.orcid0000-0002-6523-9130
dc.identifier.orcid0000-0002-1249-7240
dc.identifier.orcid0000-0001-6781-7478
dc.identifier.orcid0000-0001-6078-7480
dc.identifier.orcid0000-0002-5184-5308
dc.identifier.pmid39215440
dc.identifier.scopus2-s2.0-85202693964
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1111/echo.15918
dc.identifier.urihttps://hdl.handle.net/11616/109107
dc.identifier.volume41
dc.identifier.wosWOS:001303084100001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofEchocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250329
dc.subjectBehcet disease
dc.subjectpulmonary arterial stiffness
dc.subjectpulmonary pulse transit time
dc.subjectright ventricle
dc.titleEvaluation of right ventricular function in patients with Behcet's disease by four-dimensional echocardiography
dc.typeArticle

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