Dexmedetomidine attenuates lung injury induced by liver ischemia-reperfusion injury in rats

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dc.authoridbegeç, zekine/0000-0002-9506-1871
dc.authoridErsoy, Mehmet/0000-0002-0724-2825
dc.authoridŞahin, Taylan/0000-0002-9888-6625
dc.authoridDurmus, Mahmut/0000-0001-9594-9064
dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authorwosidbegeç, zekine/ABI-5491-2020
dc.authorwosidErsoy, Mehmet/ACN-2779-2022
dc.authorwosidsahin, taylan/IWD-9406-2023
dc.authorwosidDurmuş, Mahmut/AAG-3377-2019
dc.authorwosidŞahin, Taylan/AAT-4038-2020
dc.authorwosidElbe, Hulya/D-5261-2015
dc.authorwosidDurmus, Mahmut/ABH-3006-2020
dc.contributor.authorSahin, Taylan
dc.contributor.authorBegec, Zekine
dc.contributor.authorElbe, Hulya
dc.contributor.authorVardi, Nigar
dc.contributor.authorDurmus, Mahmut
dc.contributor.authorErsoy, M. Ozcan
dc.date.accessioned2024-08-04T20:43:04Z
dc.date.available2024-08-04T20:43:04Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives: It was aimed to evaluate histological effects of different doses of dexmedetomidine on lung injury induced by liver ischemia-reperfusion in rats. Materials and methods: Forty rats were included into the study in Inonu University Animal laboratory at 2013, In Group 1, the liver was manipulated and no occlusion of the vessels of the liver was performed. In IR Group 2, 60 min of ischemia and 60 min of reperfusion were applied. In Group 3, 10 mu g/kg of dexmedetomidine was injected into the peritoneal cavity 30 min before ischemia. In Group 4, 100 mu g/kg of dexmedetomidine was administered via intraperitoneal route 30 min before ischemia. Further procedures in groups 3 and 4 were the same as those of group 2. After the experiment was completed, the rats were killed and then histologic assessments were performed to the lung tissues. Results: Histopathological damage score in group 2 was higher than in group 1. Although lung damage was recognized as alleviated in group 3, the lesions did not completely improve. However, treatment with 100 mu g/kg of dexmedetomidine was more effective than 10 mu g/kg of dexmedetomidine injection in respect to protection of alveolar structures. The difference was found to be statistically significant between group 3 and group 4 in terms of histopathological damage score. Conclusions: The present study suggests that dexmedetomidine administration may be beneficial for preventing lung injury induced by hepatic IR.en_US
dc.identifier.endpage2455en_US
dc.identifier.issn0970-938X
dc.identifier.issn0976-1683
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-85017132221en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage2452en_US
dc.identifier.urihttps://hdl.handle.net/11616/97776
dc.identifier.volume28en_US
dc.identifier.wosWOS:000403448200013en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherScientific Publishers Indiaen_US
dc.relation.ispartofBiomedical Research-Indiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLiver ischemia-reperfusion injuryen_US
dc.subjectDexmedetomidineen_US
dc.subjectLung injuryen_US
dc.titleDexmedetomidine attenuates lung injury induced by liver ischemia-reperfusion injury in ratsen_US
dc.typeArticleen_US

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