Preventive effect of lacrimal occlusion on topical timolol-induced bronchoconstriction in asthmatics

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dc.contributor.authorHepsen, IF
dc.contributor.authorYildirim, Z
dc.contributor.authorYilmaz, H
dc.contributor.authorKotuk, M
dc.date.accessioned2024-08-04T20:13:40Z
dc.date.available2024-08-04T20:13:40Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim: To evaluate the potential preventive role of lacrimal occlusion on the topical timolol-induced bronchoconstriction in asthmatics. Methods: This was a prospective and single-masked study. Fourteen volunteer subjects with asthma were included. Collagen plugs were inserted into both canaliculi on one side to inhibit lacrimal drainage. The effect of lacrimal occlusion on lung function tests was measured before and 60 min after the instillation of a timolol drop in unplugged and plugged eyes. The spirometric measurements include forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), FEV1/FVC, and mid expiratory flow-rate (FEF25-75). Results: The timolol (0.5%) drop administration into the eye caused a significant decrease in pulmonary functions in patients with asthma in whom the lacrimal punctae had not been occluded by collagen plug. P values were 0.008 for FVC and 0.001 for FEV1 and FEF25-75. The occlusion of the lacrimal duct by intracanalicular plugs significantly reduced this decrease in pulmonary function. P values were 0.6 for FVC, 0.8 for FEV1, and 0.5 for FEF25-75. The lacrimal occlusion did not affect heart rate and blood pressures. Three subjects complained of epiphora. Conclusions: Lacrimal occlusion with intracanalicular collagen plugs may almost completely prevent the bronchoconstriction caused by topical timolol in asthmatics by inhibiting or decreasing systemic absorption of the medication.en_US
dc.identifier.doi10.1111/j.1442-9071.2004.00909.x
dc.identifier.endpage602en_US
dc.identifier.issn1442-6404
dc.identifier.issn1442-9071
dc.identifier.issue6en_US
dc.identifier.pmid15575830en_US
dc.identifier.scopus2-s2.0-11344253064en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage597en_US
dc.identifier.urihttps://doi.org/10.1111/j.1442-9071.2004.00909.x
dc.identifier.urihttps://hdl.handle.net/11616/93771
dc.identifier.volume32en_US
dc.identifier.wosWOS:000225487700009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofClinical and Experimental Ophthalmologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectasthmaen_US
dc.subjectbeta-blockeren_US
dc.subjectcollagen plugsen_US
dc.subjectspirometryen_US
dc.subjectsystemic side-effectsen_US
dc.titlePreventive effect of lacrimal occlusion on topical timolol-induced bronchoconstriction in asthmaticsen_US
dc.typeArticleen_US

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