The Preventive Effects of Chlorogenic Acid Against to Testicular Damage Caused by Methotrexate

Basit Öğe Kaydı
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridAteş, Burhan/0000-0001-6080-229X
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidAteş, Burhan/AAA-3730-2021
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidVardı, Nigar/C-9549-2018
dc.contributor.authorVardi, Nigar
dc.contributor.authorParlakpinar, Hakan
dc.contributor.authorAtes, Burhan
dc.contributor.authorOtlu, Ali
dc.date.accessioned2024-08-04T20:32:23Z
dc.date.available2024-08-04T20:32:23Z
dc.date.issued2010
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: It has been known that the agents used in cancer treatment has acute toxic side effects on tissues with high proliferative activity. Although gonadal damage is widely seen, this side effect of anticancer agents has been studied less than other side effects. Therefore, this study was conducted to demostrate whether methotrexate (MTX) caused testicular toxicity associatead with the oxidative stress, and to investigate possible protective effect of chlorogenic acid against MIX-induced testicular damage. Material and Methods: Twenty four Wistar male rats were grouped into four as control, chlorogenic acid, MTX and chlorogenic acid+MIX (combined). The obtained tissue samples were examined via histological and biochemical methods. In each group 100 tubules were classified as intact, sloughing, atrophic or degenerated. Caspase 3 immunoreactivity was evaluated according to coloring magnitude as (+) weak, (++) mild and (+++) strong. Results: It was determined that in MIX group 43.5-24.2 of tubules were sloughing, 27.5-30.2 were atrophic and 1.0-2.0 were degenerated. In combined group, a effected tubule number was statistically smaller than MIX group. Coloring density and distribution of caspase 3 in MIX group was significantly greater. It was less in the combined group. Although malondialdehyde (MDA) increased in MIX group, catalese, superoxide dismutase and glutathion peroxidase values decreased compared to controls in biochemical analysis. In combined group, except MDA, the other parametres were similar to the control group. Conclusion: We suggest that an antioxidants like chlorogenic acid may be useful for decreasing the side effects of chemotherapy.en_US
dc.identifier.doi10.5336/medsci.2008-9190
dc.identifier.endpage513en_US
dc.identifier.issn1300-0292
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-77952838939en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage507en_US
dc.identifier.urihttps://doi.org/10.5336/medsci.2008-9190
dc.identifier.urihttps://hdl.handle.net/11616/95042
dc.identifier.volume30en_US
dc.identifier.wosWOS:000277987300009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.publisherOrtadogu Ad Pres & Publ Coen_US
dc.relation.ispartofTurkiye Klinikleri Tip Bilimleri Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMethotrexateen_US
dc.subjecttestisen_US
dc.subjectapoptosisen_US
dc.titleThe Preventive Effects of Chlorogenic Acid Against to Testicular Damage Caused by Methotrexateen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu