Melatonin Prevents Cyclosporine-Induced Hepatotoxicity in Rats

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dc.authoridEşrefoğlu, Mukaddes/0000-0003-3380-1480
dc.authorwosidAtasever, Alper/Q-1150-2018
dc.authorwosidEşrefoğlu, Mukaddes/JWA-4590-2024
dc.contributor.authorKurus, Meltem
dc.contributor.authorEsrefoglu, Mukaddes
dc.contributor.authorSogutlu, Gokhan
dc.contributor.authorAtasever, Alper
dc.date.accessioned2024-08-04T20:31:16Z
dc.date.available2024-08-04T20:31:16Z
dc.date.issued2009
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives: Cyclosporine A (CsA) is a widely used immunosuppressive agent that is implicated in the formation of free oxygen radicals. Melatonin is known to be a free radical scavenger and an antioxidant agent. This study was designed to investigate the effects of melatonin on CsA-induced liver damage by histopathological examination. Materials and Methods: Thirty-two male rats of Sprague-Dawley origin were divided into 4 groups of 8 and treated for 28 days as follows: group 1 received daily doses of 0.1 ml/kg olive oil s.c.; group 2 received 4 mg/kg of melatonin; group 3 received 10 mg/kg CsA diluted in 0.1 ml/kg olive oil; group 4 was treated with 4 mg/kg melatonin i.p. and 10 mg/kg CsA s.c. Finally, the rats were sacrificed by terminal anesthesia, and liver tissue specimens were processed for light microscopy, stained with HE and examined under a light microscope. Results: Specimens of the control group showed normal liver histology, whereas group 3 showed major histopathological changes, such as cytoplasmic vacuolization, dilatation of the sinusoids, apoptosis and many mitotic figures. In group 4, the normal histology of the liver was preserved, although apoptosis, mitotic figures and cytoplasmic vacuolization were still infrequently observed. Nevertheless, there were significant differences between group 2 (melatonin) and group 3 (CsA) and between group 3 (CsA) and group 4 (CsA + melatonin) concerning these 3 parameters (vacuolization, sinusoidal dilatation and apoptosis). Conclusion: The results of this study suggest that CsA-related liver toxicity in rats could be significantly reduced by melatonin administration. Copyright (C) 2009 S. Karger AG, Baselen_US
dc.identifier.doi10.1159/000226296
dc.identifier.endpage410en_US
dc.identifier.issn1011-7571
dc.identifier.issn1423-0151
dc.identifier.issue5en_US
dc.identifier.pmid19648765en_US
dc.identifier.scopus2-s2.0-68249135331en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage407en_US
dc.identifier.urihttps://doi.org/10.1159/000226296
dc.identifier.urihttps://hdl.handle.net/11616/94846
dc.identifier.volume18en_US
dc.identifier.wosWOS:000268678200012en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofMedical Principles and Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCyclosporine Aen_US
dc.subjectMelatoninen_US
dc.subjectHepatotoxicityen_US
dc.subjectHistopathologyen_US
dc.titleMelatonin Prevents Cyclosporine-Induced Hepatotoxicity in Ratsen_US
dc.typeArticleen_US

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