Correlation of clinical, endoscopic, and histological findings with virulence factors in children with Helicobacter pylori gastritis

Simple item page
dc.authoridOTLU, BARIS/0000-0002-6220-0521
dc.authoridTurkmen, Samdanci, Emine/0000-0002-0034-5186
dc.authoridözer, ali/0000-0002-7144-4915
dc.authorwosidOTLU, BARIS/ABI-5532-2020
dc.authorwosidTurkmen, Samdanci, Emine/ABH-4716-2020
dc.authorwosidözer, ali/ABI-2209-2020
dc.contributor.authorSelimoglu, Mukadder A.
dc.contributor.authorKarabiber, Hamza
dc.contributor.authorOtlu, Baris
dc.contributor.authorYildirim, Ozge
dc.contributor.authorOzer, Ali
dc.contributor.authorSamdanci, Emine
dc.date.accessioned2024-08-04T20:39:41Z
dc.date.available2024-08-04T20:39:41Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground and goals As there are limited data regarding the correlation between virulence factors and clinical, endoscopic, and histological findings in children with Helicobacter pylori gastritis, we aimed to evaluate that probable relationship in pediatric cases. Study One hundred and fifty-nine children with chronic abdominal pain or dyspepsia were included in this study. Upper gastrointestinal endoscopy was performed and multiple biopsy samples were taken from the esophagus, the antrum, and the duodenum. PCR was used for the determination of virulence factors. Results According to PCR analysis, 98 (61.6%) children were positive for H. pylori. Using histopathological examination and culture, H. pylori was detected in 65 (40.9%) and 51 (32.1%) children, respectively. Peptic ulcer prevalence and histopathological features were not different among cagA, cagE, or iceA1 positive and negative groups (P > 0.05). Peptic ulcer prevalence and histopathological findings were more common in iceA2-positive patients (P < 0.05). Antral nodularity was more common in cagA-positive patients (P < 0.05). Endoscopic and histological features were not different among patients with or without m1 or m2 strains (P > 0.05). S1b positivity was associated with a higher esophagitis rate (P < 0.05). Conclusion Among virulence factors, iceA2 was associated with peptic ulcer and milder histopathological findings, and vacAs1 was associated with milder histopathological findings.en_US
dc.description.sponsorshipInonu University Scientific Research Projects Unit [2010/62]en_US
dc.description.sponsorshipThis study was funded by the Inonu University Scientific Research Projects Unit with the project number of 2010/62.en_US
dc.identifier.doi10.1097/MEG.0000000000000095
dc.identifier.endpage606en_US
dc.identifier.issn0954-691X
dc.identifier.issn1473-5687
dc.identifier.issue6en_US
dc.identifier.pmid24732751en_US
dc.identifier.scopus2-s2.0-84900432722en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage602en_US
dc.identifier.urihttps://doi.org/10.1097/MEG.0000000000000095
dc.identifier.urihttps://hdl.handle.net/11616/96443
dc.identifier.volume26en_US
dc.identifier.wosWOS:000335857600004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofEuropean Journal of Gastroenterology & Hepatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecthistopathologyen_US
dc.subjectHelicobacter pylorien_US
dc.subjectvirulence factorsen_US
dc.subjectchildrenen_US
dc.subjectendoscopyen_US
dc.titleCorrelation of clinical, endoscopic, and histological findings with virulence factors in children with Helicobacter pylori gastritisen_US
dc.typeArticleen_US

Files

Collections

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu

We collect and process your personal information for the following purposes: Authentication, Preferences, Acknowledgement and Statistics.
To learn more, please read our privacy policy.

Customize