Melatonin attenuates ?-adrenergic-induced contractions by increasing the release of vasoactive intestinal peptide in isolated rat penile bulb

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dc.authoridyilmaz, zehra/0000-0002-9523-7718
dc.authorwosidyılmaz, zehra/ABF-5526-2020
dc.contributor.authorOlmez, E
dc.contributor.authorKurcer, Z
dc.date.accessioned2024-08-04T20:13:27Z
dc.date.available2024-08-04T20:13:27Z
dc.date.issued2003
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe effects of melatonin on alpha-adrenergic-induced contractions caused by electrical field stimulation (EFS) or the alpha(1)-adrenoceptor agonist phenylephrine (Phe) were investigated in isolated rat penile bulb. Melatonin as well as melatonin receptor agonists N-acetylserotonin and 2-iodomelatonin and melatonin antagonist luzindole attenuated the EFS-induced contractions and the concentration-response curve to Phe. The effect of melatonin on Phe-induced contractions was completely reversed by treatment with tetrodotoxin, guanethidine or vasoactive intestinal peptide (VIP) antagonist. On the other hand, pretreatment with N-methyl-l-arginine, atropine, and luzindole did not reverse the effect of melatonin. Thus, we demonstrated that melatonin at nanomolar concentrations inhibits the alpha-adrenergic responses in isolated rat penile bulb. Since alpha-adrenoceptor blocking agents are known to interfere with detumescence of the erect penis, serum levels or administration of this pineal hormone may affect erectile function. This effect of melatonin may be the result of its allosteric interaction with the presynaptic receptors on VIPergic neurons, which are affected by sympathetic transmission, and then an increase in VIP release from these neurons.en_US
dc.identifier.doi10.1007/s00240-003-0327-0
dc.identifier.endpage279en_US
dc.identifier.issn0300-5623
dc.identifier.issn1434-0879
dc.identifier.issue4en_US
dc.identifier.pmid12844242en_US
dc.identifier.scopus2-s2.0-0141792373en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage276en_US
dc.identifier.urihttps://doi.org/10.1007/s00240-003-0327-0
dc.identifier.urihttps://hdl.handle.net/11616/93628
dc.identifier.volume31en_US
dc.identifier.wosWOS:000184902700010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofUrological Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectmelatoninen_US
dc.subjectalpha-adrenergic contractionsen_US
dc.subjectrat penile bulben_US
dc.titleMelatonin attenuates ?-adrenergic-induced contractions by increasing the release of vasoactive intestinal peptide in isolated rat penile bulben_US
dc.typeArticleen_US

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