Protective effects of apocynin on cisplatin induced hepatotoxicity in rats

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dc.authoridTR116272en_US
dc.authoridTR118674en_US
dc.authoridTR102000en_US
dc.authoridTR100549en_US
dc.authoridTR45132en_US
dc.authoridTR58662en_US
dc.authoridTR125476en_US
dc.contributor.authorÇağın, Yasir Furkan
dc.contributor.authorErdoğan, Mehmet Ali
dc.contributor.authorŞahin, Nurhan
dc.contributor.authorParlakpınar, Hakan
dc.contributor.authorAtayan, Yahya
dc.contributor.authorPolat, Alaadin
dc.contributor.authorVardı, Nigar
dc.contributor.authorYıldız, Azibe
dc.contributor.authorTanbek, Kevser
dc.date.accessioned2017-04-11T10:19:04Z
dc.date.available2017-04-11T10:19:04Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground and Aims. Despite it being a highly potent antineoplastic drug, cisplatin has important toxic adverse effects limiting its use such as nephrotoxicity, neurotoxicity and ototoxicity. It is thought that cisplatin-induced hepatotoxicity is caused by oxidative stress resulting from increased reactive oxygen species (ROS). Apocynin (APO) exerts its antioxidant effect by reducing ROS production via inhibition of NADPH oxidase. The present study intended to demonstrate effects of cisplatin on hepatic pro-oxidant/ antioxidant systems and to investigate protective effects of APO against cisplatininduced hepatotoxicity. Methods. Rats were randomly assigned into four groups (n 5 8 each): a) control group; b) single dose of cisplatin (5 mg/kg); c) APO group (20 mg/kg on three consecutive days; i.p.); and d) APO plus cisplatin group. Liver tissue was assessed in all groups by biochemical and histopathological means. Also, serum alanine transaminase (ALT), aspartate transaminase (AST) and alkaline phosphatase levels were studied in all groups. Results. When cisplatin group was compared to controls, it was seen that lipid peroxidation product, total oxidant status and ALT levels were markedly increased, whereas superoxide dismutase and glutathione peroxidase levels were overtly decreased. APO therapy markedly prevented cisplatin-induced harmful changes in liver. Our histopathological findings such as central vein dilatation, perivenuler and periportal sinusoidal dilatation, parenchymal inflammation, vacuolar changes in hepatocytes, biliary duct proliferation and caspase-3 positive hepatocytes were in accordance with the biochemical changes. Conclusion. In light of these results, it is our thought that APO has a protective role against cisplatin-induced hepatotoxicity at both biochemical and histopathological levels.en_US
dc.identifier.citationÇağın, Y. F. Erdoğan, M. A. Şahin, N. Parlakpınar, H. Atayan, Y. Polat, A. Vardı, N. Yıldız, A. Tanbek, K. (2015). Protective effects of apocynin on cisplatin induced hepatotoxicity in rats. Archives of medical research. 517-526 ss.en_US
dc.identifier.doi10.1016/j.arcmed.2015.08.005en_US
dc.identifier.endpage526en_US
dc.identifier.issn01884409
dc.identifier.startpage517en_US
dc.identifier.urihttp://linkinghub.elsevier.com/retrieve/pii/S0188440915002131
dc.identifier.urihttps://hdl.handle.net/11616/6630
dc.identifier.volume46en_US
dc.language.isoenen_US
dc.publisherArchives of medical researchen_US
dc.relation.ispartofArchives of medical researchen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCisplatinen_US
dc.subjectApocyninen_US
dc.subjectHepatotoxicityen_US
dc.subjectOxidative stressen_US
dc.titleProtective effects of apocynin on cisplatin induced hepatotoxicity in ratsen_US
dc.typeArticleen_US

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