Comparison of effects of propofol and ketamine-propofol mixture (ketofol) on laryngeal mask airway insertion conditions and hemodynamics in elderly patients: a randomized, prospective, double-blind trial

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dc.authoridYücel, Aytaç/0000-0003-0270-8339
dc.authoridDurmus, Mahmut/0000-0001-9594-9064
dc.authoridbegeç, zekine/0000-0002-9506-1871
dc.authoridÇOLAK, CEMİL/0000-0001-5406-098X
dc.authoridaydogan, mustafa said/0000-0002-7106-1156
dc.authoridOZGUL, Ulku/0000-0003-3738-1751
dc.authoridErdogan, Mehmet Ali/0000-0002-3860-6919
dc.authorwosidYücel, Aytaç/ABI-6137-2020
dc.authorwosidErdogan, Mehmet Ali/ABI-7224-2020
dc.authorwosidDurmus, Mahmut/ABH-3006-2020
dc.authorwosidbegeç, zekine/ABI-5491-2020
dc.authorwosidÇOLAK, CEMİL/ABI-3261-2020
dc.authorwosidaydogan, mustafa said/AAA-2828-2021
dc.authorwosidDurmuş, Mahmut/AAG-3377-2019
dc.contributor.authorErdogan, Mehmet Ali
dc.contributor.authorBegec, Zekine
dc.contributor.authorAydogan, Mustafa Said
dc.contributor.authorOzgul, Ulku
dc.contributor.authorYucel, Aytac
dc.contributor.authorColak, Cemil
dc.contributor.authorDurmus, Mahmut
dc.date.accessioned2024-08-04T20:37:26Z
dc.date.available2024-08-04T20:37:26Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe objective of this study was to compare the effects of ketamine-propofol mixture (ketofol) and propofol on ProSeal laryngeal mask airway (PLMA) insertion conditions and hemodynamics in elderly patients. Eighty elderly patients, American Society of Anesthesiologists (ASA) physical status I and II, were randomly divided into two groups to receive either propofol 0.15 ml/kg (n = 40), or ketofol (using a 1:1 single-syringe mixture of 5 mg/ml ketamine and 5 mg/ml propofol) (n = 40) before induction of anesthesia. Sixty seconds after induction, the PLMA was inserted. Heart rate and arterial blood pressure (systolic [S] BP) were recorded prior to the induction of anesthesia, immediately following induction, immediately after PLMA insertion, and 5 and 10 min after PLMA insertion. PLMA insertion conditions were scored according to mouth opening, swallowing, coughing, head and body motion, laryngospasm, and ease of PLMA insertion by the same experienced anesthesiologist, who did not know which agents were used. There were no differences in PLMA insertion conditions between the groups. The number of patients in need of ephedrine (P = 0.043) and the total dose of ephedrine (P = 0.022) were significantly lower, and apnea duration (P < 0.001) was significantly higher in the ketofol group compared with the propofol group. SBP was significantly higher in the ketofol group than in the propofol group immediately after PLMA insertion and 5 min after PLMA insertion. The same PLMA insertion conditions were found with ketofol and propofol. The number of patients in need of ephedrine and the total ephedrine dose were lower and apnea duration was increased in the ketofol group.en_US
dc.identifier.doi10.1007/s00540-012-1484-5
dc.identifier.endpage17en_US
dc.identifier.issn0913-8668
dc.identifier.issn1438-8359
dc.identifier.issue1en_US
dc.identifier.pmid22972566en_US
dc.identifier.scopus2-s2.0-84874115643en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage12en_US
dc.identifier.urihttps://doi.org/10.1007/s00540-012-1484-5
dc.identifier.urihttps://hdl.handle.net/11616/95964
dc.identifier.volume27en_US
dc.identifier.wosWOS:000315042200003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Japan Kken_US
dc.relation.ispartofJournal of Anesthesiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPropofolen_US
dc.subjectKetamineen_US
dc.subjectLaryngeal mask airwayen_US
dc.subjectElderly patientsen_US
dc.titleComparison of effects of propofol and ketamine-propofol mixture (ketofol) on laryngeal mask airway insertion conditions and hemodynamics in elderly patients: a randomized, prospective, double-blind trialen_US
dc.typeArticleen_US

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