Demographic and microbial characteristics of extrapulmonary tuberculosis cases diagnosed in Malatya, Turkey, 2001-2007

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dc.authoridkoroglu, mehmet/0000-0001-8101-1104
dc.authoridGünal, Selami/0000-0002-4752-5176
dc.authoridAgarwal, Mansi/0000-0002-0367-7733
dc.authoridDURMAZ, RIZA/0000-0001-6561-778X
dc.authorwosidkoroglu, mehmet/HTN-0171-2023
dc.authorwosidGünal, Selami/AAA-7246-2021
dc.authorwosidDURMAZ, Rıza/HJH-4918-2023
dc.contributor.authorGunal, Selami
dc.contributor.authorYang, Zhenhua
dc.contributor.authorAgarwal, Mansi
dc.contributor.authorKoroglu, Mehmet
dc.contributor.authorArici, Zeynep Kazgan
dc.contributor.authorDurmaz, Riza
dc.date.accessioned2024-08-04T20:32:44Z
dc.date.available2024-08-04T20:32:44Z
dc.date.issued2011
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Extrapulmonary tuberculosis (EPTB) has an increasing rate in Turkey. The reason remains largely unknown. A better understanding of the demographic and microbial characteristics of EPTB in the Turkish population would extend the knowledgebase of EPTB and allow us to develop better strategies to control tuberculosis (TB). Methods: We retrospectively evaluated clinical and laboratory data of 397 bacteriologically-confirmed TB cases diagnosed during an eight year-period using by chi-square analysis and multivariate logistic regression model. Results: Of the 397 study patients, 103 (25.9%) had EPTB and 294 (74.1%) had pulmonary tuberculosis (PTB). The most commonly seen two types of EPTB were genitourinary TB (27.2%) and meningeal TB (19.4%). TB in bone/joints, pleural cavity, lymph nodes, skin, and peritoneal cavity occurred at a frequency ranging from 9.7% to 10.7%. The age distribution was significantly different (P < 0.01) between PTB and EPTB, with patients older than 45 years tending to have an increased risk of EPTB. Furthermore, the distribution of different types of EPTB differed significantly among age groups (P = 0.03). Meningeal and bone and/or joint TB were more commonly observed among the male patients, while lymphatic, genitourinary, and peritoneal TB cases were more frequently seen among females. Unique strain infection was statistically significantly associated with EPTB (OR: 2.82, 95% CI [1.59, 5.00]). Conclusions: EPTB accounted for a significant proportion of TB cases in Malatya, Turkey between 2001 and 2007. The current study has provided an insight into the dynamics of EPTB in Malatya, Turkey. However, the risk factors for having EPTB in Malatya, Turkey remain to be assessed in future studies using population-based or randomly selected sample.en_US
dc.description.sponsorshipMolecular and Clinical Microbiology Society, Malatya/Turkey; University of Michiganen_US
dc.description.sponsorshipWe thank Drs. Ercument Evliyaoglu, Onder Turk, and Sahin Temiz at the Malatya Tuberculosis Dispensary for their assistance in the collection of the study isolates. This study was supported by a grant from the Molecular and Clinical Microbiology Society, Malatya/Turkey to Dr. Riza Durmaz and the Elizabeth Crosby Award of the University of Michigan to Dr. Zhnehua Yang.en_US
dc.identifier.doi10.1186/1471-2458-11-154
dc.identifier.issn1471-2458
dc.identifier.pmid21385458en_US
dc.identifier.scopus2-s2.0-79952353828en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1186/1471-2458-11-154
dc.identifier.urihttps://hdl.handle.net/11616/95271
dc.identifier.volume11en_US
dc.identifier.wosWOS:000288496800001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBiomed Central Ltden_US
dc.relation.ispartofBmc Public Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMycobacterium-Tuberculosisen_US
dc.subjectExtrathoracic Tuberculosisen_US
dc.subjectPulmonary Tuberculosisen_US
dc.subjectGenetic Diversityen_US
dc.subjectEpidemiologyen_US
dc.subjectIdentificationen_US
dc.titleDemographic and microbial characteristics of extrapulmonary tuberculosis cases diagnosed in Malatya, Turkey, 2001-2007en_US
dc.typeArticleen_US

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