Beneficial effects of quercetin on renal injury and oxidative stress caused by ciprofloxacin in rats: A histological and biochemical study

Basit Öğe Kaydı
dc.authoridTaslidere, Elif/0000-0003-1723-2556
dc.authoridTürköz, Yusuf/0000-0001-5401-0720
dc.authoridTaşlidere, Aslı Cetin/0000-0003-3902-3210;
dc.authorwosidTaslidere, Elif/ABI-8046-2020
dc.authorwosidTürköz, Yusuf/ABG-7931-2020
dc.authorwosidElbe, Hulya/D-5261-2015
dc.authorwosidDogan, Zumrut yılmaz/V-5131-2018
dc.authorwosidTaşlidere, Aslı Cetin/AAB-3979-2021
dc.authorwosidDoğan, Zümrüt/GQP-2535-2022
dc.contributor.authorElbe, H.
dc.contributor.authorDogan, Z.
dc.contributor.authorTaslidere, E.
dc.contributor.authorCetin, A.
dc.contributor.authorTurkoz, Y.
dc.date.accessioned2024-08-04T20:41:29Z
dc.date.available2024-08-04T20:41:29Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractCiprofloxacin is a broad-spectrum quinolone antibiotic commonly used in clinical practice. Quercetin is an antioxidant belongs to flavonoid group. It inhibits the production of superoxide anion. In this study, we aimed to evaluate the effects of quercetin on renal injury and oxidative stress caused by ciprofloxacin. Twenty-eight female Wistar albino rats were divided into four groups: control, quercetin (20 mg kg(-1) day(-1) gavage for 21 days), ciprofloxacin (20 mg kg(-1) twice a day intraperitoneally for 10 days), and ciprofloxacin + quercetin. Samples were processed for histological and biochemical evaluations. Malondialdehyde (MDA) and glutathione (GSH) levels, superoxide dismutase (SOD), and catalase (CAT) activities were measured in kidney tissue. The ciprofloxacin group showed histopathological changes such as infiltration, dilatation in tubules, tubular atrophy, reduction of Bowman's space, congestion, hemorrhage, and necrosis. In the ciprofloxacin + quercetin group, these histopathological changes markedly reduced. MDA levels increased in the ciprofloxacin group and decreased in the ciptofloxacin + quercetin group. SOD and CAT activities and GSH levels significantly decreased in the ciprofloxacin group. On the other hand, in the ciprofloxacin + quercetin group, SOD and CAT activities and GSH levels significantly increased with regard to the ciprofloxacin group. We concluded that quercetin has antioxidative and therapeutic effects on renal injury and oxidative stress caused by ciprofloxacin in rats.en_US
dc.description.sponsorshipInonu University Scientific Research Project Uniten_US
dc.description.sponsorshipThis study was financially supported by Inonu University Scientific Research Project Unit.en_US
dc.identifier.doi10.1177/0960327115584686
dc.identifier.endpage281en_US
dc.identifier.issn0960-3271
dc.identifier.issn1477-0903
dc.identifier.issue3en_US
dc.identifier.pmid25929518en_US
dc.identifier.scopus2-s2.0-84957616516en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage276en_US
dc.identifier.urihttps://doi.org/10.1177/0960327115584686
dc.identifier.urihttps://hdl.handle.net/11616/97160
dc.identifier.volume35en_US
dc.identifier.wosWOS:000369657300008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofHuman & Experimental Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCiprofloxacinen_US
dc.subjectoxidative stressen_US
dc.subjectrenal injuryen_US
dc.subjectquercetinen_US
dc.titleBeneficial effects of quercetin on renal injury and oxidative stress caused by ciprofloxacin in rats: A histological and biochemical studyen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu