Association between RAS gene polymorphisms (ACE I/D, AGT M235T) and Henoch-Schonlein purpura in a Turkish population
dc.authorid | Serdaroglu, Erkin/0000-0002-6863-8866 | |
dc.authorid | Serdaroglu, Erkin/0000-0002-6863-8866 | |
dc.authorwosid | Tabel, Yilmaz/AAF-9801-2020 | |
dc.authorwosid | Serdaroglu, Erkin/N-3838-2019 | |
dc.authorwosid | Serdaroglu, Erkin/E-9547-2016 | |
dc.contributor.author | Nalbantoglu, Sinem | |
dc.contributor.author | Tabel, Yilmaz | |
dc.contributor.author | Mir, Sevgi | |
dc.contributor.author | Serdaroglu, Erkin | |
dc.contributor.author | Berdeli, Afig | |
dc.date.accessioned | 2024-08-04T20:37:23Z | |
dc.date.available | 2024-08-04T20:37:23Z | |
dc.date.issued | 2013 | |
dc.department | İnönü Üniversitesi | en_US |
dc.description.abstract | Henoch-Schonlein purpura (HSP) is a small-vessel vasculitis of autoimmune hypersensitivity, and renin-angiotensin system (RAS) regulates vascular homeostasis and inflammation with activation of cytokine release. Thus, we aimed to investigate the association between HSP and ACE I/D and AGT M235T polymorphisms. Genotyping was determined by allele specific PCR and PCR-RFLP. We obtained a significant difference in genotype distribution (p = 0.003) and allele frequencies (p < 0.001) of ACE I/D polymorphism between patients and controls, while no significant association was detected in genotype distribution (p > 0.05) and allele frequencies (p > 0.05) of the AGT M235T polymorphism. Risk assessment showed significant risk for HSP in the subjects both with the ID + DD genotype (p = 0.019, OR: 2.288, 95% CI: 1.136-4.609) and D allele (OR: D vs. I: 2.0528, 95% CI: 1.3632-3.0912, p = 0.001) while no significant risk was obtained for HSP in the subjects both with the MT + TT genotype (p = 0.312, OR: 1.3905, 95% CI: 0.7326-2.6391) and T allele (OR: T vs. M: 1.065, 95% CI: 0.729-1.557, p = 0.743). Furthermore, when patients were stratified by the presence of certain systemic complications of HSP, no significant association was detected with ACE I/D, and AGT M235T polymorphisms. Our findings suggest that ACE I/D polymorphism is significantly associated with HSP susceptibility. | en_US |
dc.identifier.doi | 10.1155/2013/624757 | |
dc.identifier.endpage | 32 | en_US |
dc.identifier.issn | 0278-0240 | |
dc.identifier.issn | 1875-8630 | |
dc.identifier.issue | 1 | en_US |
dc.identifier.pmid | 23151617 | en_US |
dc.identifier.scopus | 2-s2.0-84872288348 | en_US |
dc.identifier.scopusquality | Q2 | en_US |
dc.identifier.startpage | 23 | en_US |
dc.identifier.uri | https://doi.org/10.1155/2013/624757 | |
dc.identifier.uri | https://hdl.handle.net/11616/95921 | |
dc.identifier.volume | 34 | en_US |
dc.identifier.wos | WOS:000312597200004 | en_US |
dc.identifier.wosquality | Q2 | en_US |
dc.indekslendigikaynak | Web of Science | en_US |
dc.indekslendigikaynak | Scopus | en_US |
dc.indekslendigikaynak | PubMed | en_US |
dc.language.iso | en | en_US |
dc.publisher | Hindawi Ltd | en_US |
dc.relation.ispartof | Disease Markers | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Henoch-Schonlein purpura (HSP) | en_US |
dc.subject | ACE I/D | en_US |
dc.subject | AGT M235T | en_US |
dc.subject | Single Nucleotide Polymorphism (SNP) | en_US |
dc.subject | organ involvements | en_US |
dc.subject | Genotype-phenotype correlation | en_US |
dc.title | Association between RAS gene polymorphisms (ACE I/D, AGT M235T) and Henoch-Schonlein purpura in a Turkish population | en_US |
dc.type | Article | en_US |