Investigation of the cytotoxic effect of Lallemantia Fisch. & C.A. Mey. species growing in Türkiye on various cancer cell lines

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dc.contributor.authorÇelik, Ali Kaya
dc.contributor.authorSancar, Pelin Yılmaz
dc.contributor.authorTaşkın, Irmak İçen
dc.contributor.authorKürşat, Murat
dc.date.accessioned2024-08-04T19:42:48Z
dc.date.available2024-08-04T19:42:48Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe genus Lallemantia (Lamiaceae) is popularly known as "Dragonhead". The genus, which has been proven to have extremely rich compounds, is used in the treatment of many diseases among the people. The genus is represented by 5 taxa in the world and 3 taxa are naturally distributed in Türkiye. In this study, the cytotoxic properties of methanolic extracts of the above-ground parts of Lallemantia peltata, Lallemantia iberica and Lallemantia canescens taxa were investigated against BEAS-2B, SH-SY5Y, HCT 116 and Hep G2 cell lines. Changes in the viability of cancer cells were determined using the MTT method. The results showed that all three species had varying degrees of cytotoxic effect. This effect was maximum in L. canescens with 53.54% (p<0.001) on HCT 116, 37.53% (p=0.005) on SH-SY5Y and 32.03% (p=0.026) on Hep G2 at 800 ?g/ml and minimum in L. iberica. In addition, the herbal extracts had no toxic effect on healthy lung cells (BEAS-2B).en_US
dc.identifier.doi10.17474/artvinofd.1403978
dc.identifier.endpage110en_US
dc.identifier.issn2146-1880
dc.identifier.issn2146-698X
dc.identifier.issue1en_US
dc.identifier.startpage104en_US
dc.identifier.trdizinid1237387en_US
dc.identifier.urihttps://doi.org/10.17474/artvinofd.1403978
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1237387
dc.identifier.urihttps://hdl.handle.net/11616/88680
dc.identifier.volume25en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofArtvin Çoruh Üniversitesi Orman Fakültesi Dergisien_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleInvestigation of the cytotoxic effect of Lallemantia Fisch. & C.A. Mey. species growing in Türkiye on various cancer cell linesen_US
dc.typeArticleen_US

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