Dynamic MRI in indirect estimation of microvessel density, histologic grade, and prognosis in colorectal adenocarcinomas

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dc.authoridKarakas, Hakki/0000-0002-1328-8520
dc.contributor.authorTuncbilek, N
dc.contributor.authorKarakas, HM
dc.contributor.authorAltaner, S
dc.date.accessioned2024-08-04T20:13:48Z
dc.date.available2024-08-04T20:13:48Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe relations of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) parameters to microvessel density (MVD), histologic grade, and presence of metastasis were evaluated to establish new prognostic indicators in colorectal cancer (CRC). Fast-low angle shot DCE-MRI parameters (time-intensity curves, TICs; maximal relative enhancement within the first minute, E-max/1; maximal relative enhancement of the entire study, E-max; steepest slope of the contrast enhancement curve; and time to peak enhancement) of 21 CRCs (seven Duke stage B, 12 Duke stage C, and two Duke stage D) were retrospectively evaluated and correlated with corresponding postoperative MVD measurements, histologic grades, and presence of metastasis at 2 years. TICs were classified as type A in nine (43%), type B in seven (33%), and type C in five cases (24%). There was a significant difference between TIC types with regard to MVD (p < 0.05-0.001). Time to peak enhancement, steepest slope of TIC, and E-max/1 were strongly correlated with MVD (r = -0.765, p < 0.01; r = 0.681, p < 0.01; r = 0.634, p < 0.01; respectively). MVD, steepest slope of the enhancement curve, E-max/1, and E-max strongly correlated with histologic grade (r = 0.475, p < 0.05; r = 0.683, p < 0.01; r = 0.687, p < 0.01; r = 0.791, p < 0.01; respectively). There was a significant difference between groups of patients with and without metastasis with regard to histologic grade (p < 0.05) and two of the DCE-MRI parameters (p < 0.005 for E-max/1 and p < 0.05 for time to peak enhancement). Discriminant analysis correctly predicted the metastatic occurrence at 2 years in 90.5% of cases using E-max/1 (p < 0.001). Histologic grade resulted in lower rates of discrimination (66.7%; p < 0.05). DCE-MRI parameters may help in the prediction of MVD and histologic grade in CRC and may be used to predict therapeutic outcome.en_US
dc.identifier.doi10.1007/s00261-003-0090-2
dc.identifier.endpage172en_US
dc.identifier.issn0942-8925
dc.identifier.issue2en_US
dc.identifier.pmid15290941en_US
dc.identifier.scopus2-s2.0-1642303272en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage166en_US
dc.identifier.urihttps://doi.org/10.1007/s00261-003-0090-2
dc.identifier.urihttps://hdl.handle.net/11616/93863
dc.identifier.volume29en_US
dc.identifier.wosWOS:000220252500006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer-Verlagen_US
dc.relation.ispartofAbdominal Imagingen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcolorectal canceren_US
dc.subjectdynamic magnetic resonance imagingen_US
dc.subjectcontrast enhancementen_US
dc.subjectangiogenesisen_US
dc.subjectmicrovessel densityen_US
dc.subjectprognostic indicatorsen_US
dc.titleDynamic MRI in indirect estimation of microvessel density, histologic grade, and prognosis in colorectal adenocarcinomasen_US
dc.typeArticleen_US

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