The effect of Hypericum Perforatum on wound healing of oral mucosa in diabetic rats

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dc.authoridAltan, Ahmet/0000-0003-2041-6364
dc.authoridGokce, Hasan/0000-0002-4658-9987
dc.authoridAltan, Ahmet/0000-0003-2041-6364
dc.authoridAlpaslan, Cansu/0000-0003-2092-7842
dc.authoridARAS, Mutan/0000-0002-8907-7340
dc.authorwosidAltan, Ahmet/ABE-7069-2020
dc.authorwosidGokce, Hasan/ABH-2400-2020
dc.authorwosidAltan, Ahmet/N-9241-2015
dc.authorwosidAlpaslan, Cansu/ABG-3896-2021
dc.contributor.authorAltan, Ahmet
dc.contributor.authorAras, Mutan Hamdi
dc.contributor.authorDamlar, Ibrahim
dc.contributor.authorGokce, Hasan
dc.contributor.authorOzcan, Oguzhan
dc.contributor.authorAlpaslan, Cansu
dc.date.accessioned2024-08-04T20:10:31Z
dc.date.available2024-08-04T20:10:31Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose This study aims to investigate the histopathological and biochemical effects of the topical application of Hypericum perforatum on the healing of surgical wounds created in the oral mucosa of rats with experimentally induced diabetes mellitus. Materials and methods The study was carried out on 48 adult male Wistar albino rats. The animals were divided into two main groups as control and study groups. Two main groups were divided into three subgroups according to the sacrification days. All rats were given streptozotocin 60 mg/kg, after 72 hours, and those having blood glucose levels above 200 mg/dL were included in the study. Mucosal defects were created in the palatal area of the rats. H. perforatum oil was applied topically twice a day to the wounds of the rats in the study group. Animal were sacrificed on the 3rd, 7th and 10th days and samples taken from the palatal wounds were examined histologically and biochemically. Results On the 7th day, ulceration, necrosis, epithelialization, polymorphonuclear leucocytes and hydroxyproline variables showed statistically significant differences (p<0.05). Ulceration, necrosis and polymorphonuclear leukocytes values were higher in the control group, whereas epithelialization and hydroxyproline values were found to be higher in the H. perforatum group. Among 10th-day groups, there was only a statistically significant difference between the values of hydroxyproline, whereas H. perforatum-treated group showed high hydroxyproline levels (p<0.05). Conclusion Topically applied H. perforatum did not create any difference on the 3rd day, but it has positively affected the wound healing on the 7th and 10th days in diabetic rats.en_US
dc.description.sponsorshipresearch foundation of Mustafa Kemal University [12023]en_US
dc.description.sponsorshipThis project was supported with a grant from the research foundation of Mustafa Kemal University (project no: 12023).en_US
dc.identifier.doi10.26650/eor.2018.505
dc.identifier.endpage149en_US
dc.identifier.issn2630-6158
dc.identifier.issn2651-2823
dc.identifier.issue3en_US
dc.identifier.pmid30775718en_US
dc.identifier.startpage143en_US
dc.identifier.trdizinid347557en_US
dc.identifier.urihttps://doi.org/10.26650/eor.2018.505
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/347557
dc.identifier.urihttps://hdl.handle.net/11616/92828
dc.identifier.volume52en_US
dc.identifier.wosWOS:000488845600006en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherIstanbul Univ Press, Istanbul Univ Rectorateen_US
dc.relation.ispartofEuropean Oral Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDiabetes mellitusen_US
dc.subjectH. perforatumen_US
dc.subjectoral mucosaen_US
dc.subjectSt. John's Worten_US
dc.subjectwound healingen_US
dc.titleThe effect of Hypericum Perforatum on wound healing of oral mucosa in diabetic ratsen_US
dc.typeArticleen_US

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