Synthesis of 3,6-disubstituted 7H-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazines as novel analgesic/anti-inflammatory compounds

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dc.authoridÜnüvar, Songül/0000-0001-8454-490X
dc.authoridAKTAY, Goknur/0000-0002-1646-8674
dc.authorwosidÜnüvar, Songül/ABH-5516-2020
dc.authorwosidKaynak, Filiz Betül/E-7489-2013
dc.authorwosidAytac, Peri/AGY-9153-2022
dc.contributor.authorAytac, S. Peri
dc.contributor.authorTozkoparan, Birsen
dc.contributor.authorKaynak, F. Betuel
dc.contributor.authorAktay, Goeknur
dc.contributor.authorGoektas, Oezguer
dc.contributor.authorUenuevar, Songuel
dc.date.accessioned2024-08-04T20:31:20Z
dc.date.available2024-08-04T20:31:20Z
dc.date.issued2009
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this study, a new class of 4-amino-3-substituted-1,2,4-triazole-5-thiones (1-4) and their corresponding condensed derivatives 3,6-disubstituted 7H-1,2,4-triazolo[3,4-bi-1,3,4-thiadiazines (1a-4c) were synthesized and evaluated for their analgesic/anti-inflammatory activities. All synthesized compounds were also tested for their gastric toxicity and antioxidant activity on acute administration. Most of the compounds showed significant activity in both carrageenan-induced oedema and acetic acid-induced writhing tests besides negligible gastrointestinal toxicity. The compounds showing less ulcerogenic effect also showed less lipid peroxidation (LPO) level. Most promising results were obtained with the compounds that placed a fluoro or a chloride on the phenyl ring at the sixth position of the fused ring. (C) 2009 Elsevier Masson SAS. All rights reserved.en_US
dc.description.sponsorship(Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Ankara, Turkey); Hacettepe University Research Center [0701301001, 0302602001]en_US
dc.description.sponsorshipThe authors express deep thanks to Prof. Dr. M. Ertan (Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Ankara, Turkey) and Hacettepe University Research Center for their financial supports (P.N.: 0701301001 and 0302602001).en_US
dc.identifier.doi10.1016/j.ejmech.2009.06.026
dc.identifier.endpage4538en_US
dc.identifier.issn0223-5234
dc.identifier.issn1768-3254
dc.identifier.issue11en_US
dc.identifier.pmid19632747en_US
dc.identifier.scopus2-s2.0-70349777308en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage4528en_US
dc.identifier.urihttps://doi.org/10.1016/j.ejmech.2009.06.026
dc.identifier.urihttps://hdl.handle.net/11616/94886
dc.identifier.volume44en_US
dc.identifier.wosWOS:000271225800032en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier France-Editions Scientifiques Medicales Elsevieren_US
dc.relation.ispartofEuropean Journal of Medicinal Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAminomercaptotriazolesen_US
dc.subjectTriazolothiadiazinesen_US
dc.subjectAnalgesic/anti-inflammatory activityen_US
dc.subjectAntioxidant activityen_US
dc.titleSynthesis of 3,6-disubstituted 7H-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazines as novel analgesic/anti-inflammatory compoundsen_US
dc.typeArticleen_US

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