Evaluation of the Appropriateness of Antimicrobial Drug Dosages in Intensive Care Unit Patients

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dc.authorscopusid57221765512
dc.authorscopusid58628055900
dc.authorscopusid57219039015
dc.authorscopusid57289798700
dc.contributor.authorMemiş H.
dc.contributor.authorÇakir A.
dc.contributor.authorÖzdemir N.
dc.contributor.authorGün Z.Ü.
dc.date.accessioned2024-08-04T20:00:59Z
dc.date.available2024-08-04T20:00:59Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe purpose of this study was to investigate the factors that required dose adjustments of antimicrobial drugs in intensive care unit (ICU) patients and to identify the drugs that required the most dose adjustments. The current prospective study was conducted in the reanimation ICU with 26-bed capacity of a university-af-filiated hospital from September to December 2022. Two clinical pharmacists on duty examined patients’ antimicrobial drug dosages daily. The acceptance status of the recommendations and the patients’ demographic information were recorded. The study involved 133 ICU patients, and antimicrobial drug recommendations were made for 48 patients, 31 (64.6%) of whom were male. The median (IQR) age of the 48 patients was 67 (54–77). The count of recommendations was 94, and the acceptance rate was 100%. The recommendation rates were as follows: 71.3% for renal function, 11.7% for presence of continuous renal replacement therapy, 10.6% for indication, 4.3% for body weight, and 2.1% for loading dose. The top 3 drugs for which recommendations were made the most were colistin (21.3%), meropenem (18.1%), and piperacillin-tazobactam (12.8%). The most troublesome drug was colistin, which is frequently used to treat Acinetobacter pneumonia. Clinical pharmacist and physician collaboration may help rationalize ICU antimicrobial drug use. © 2024, Hacettepe University, Faculty of Pharmacy. All rights reserved.en_US
dc.identifier.doi10.52794/hujpharm.1302724
dc.identifier.endpage45en_US
dc.identifier.issn1300-0608
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85186627597en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage38en_US
dc.identifier.urihttps://doi.org/10.52794/hujpharm.1302724
dc.identifier.urihttps://hdl.handle.net/11616/91150
dc.identifier.volume44en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherHacettepe University, Faculty of Pharmacyen_US
dc.relation.ispartofHacettepe University Journal of the Faculty of Pharmacyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntimicrobial drugsen_US
dc.subjectclinical pharmacisten_US
dc.subjectcolistinen_US
dc.subjectintensive care uniten_US
dc.subjectmeropenemen_US
dc.titleEvaluation of the Appropriateness of Antimicrobial Drug Dosages in Intensive Care Unit Patientsen_US
dc.typeArticleen_US

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