Prevalence and clinical significance of a patent foramen ovate in patients with chronic obstructive pulmonary disease

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dc.authoridHacievliyagil, Suleyman Savas/0000-0002-2572-1870
dc.authoridGunen, Hakan/0000-0001-6631-4457
dc.authoridKilic, Talat/0000-0001-8125-9062
dc.authorwosidHacievliyagil, Suleyman Savas/ABI-7307-2020
dc.authorwosidGunen, Hakan/HKV-9202-2023
dc.authorwosidKilic, Talat/ABI-4457-2020
dc.contributor.authorHacievliyagil, SS
dc.contributor.authorGunen, H
dc.contributor.authorKosar, FM
dc.contributor.authorSahin, I
dc.contributor.authorKilic, T
dc.date.accessioned2024-08-04T20:15:23Z
dc.date.available2024-08-04T20:15:23Z
dc.date.issued2006
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: A patent foramen ovate (PFO) is not widely recognized as a factor contributing to hypoxemia in patients with chronic obstructive pulmonary disease (CCPD). We therefore sought to clarify the prevalence and clinical significance of a PFO in patients with COPD, and to analyze the factors related to its occurrence. Methods: This study included 52 consecutive stable patients with COPD and 50 healthy controls. The demographic and clinical features of the study group were noted. To test for a PFO, standard and contrast transthoracic echocardiographic examinations were performed while resting and during the Valsalva maneuver (VM). Patients performed 6-min walking tests (6 MWT), and the distances traveled were measured. Results: During VM, we detected a PFO in 23 COPD patients and 10 healthy controls (P < 0.01). A PFO was detected while resting in 11 COPD patients, but in none of the controls (P = 0.001). Comparison of multiple parameters between COPD patients with and without a PFO during VM did not reveal any clinically significant differences. When we compared COPD patients with and without a PFO during resting, however, we found that the former had longer durations of disease, lower PaO2 and SaO(2), higher dyspnea scores, shorter distances walked during 6 MWT and higher desaturation rates (P < 0.05). Logistic regression analysis showed that longer duration of disease, lower SaO(2) and higher systolic pulmonary artery pressure were independent predictors of the occurrence of a PFO in resting COPD patients. Conclusions: The prevalence of a PFO is higher in patients with COPD than in healthy individuals. The presence of a PFO while resting may contribute significantly to the deterioration of arterial oxygenation and performance status. These findings indicate that a PFO may be a principle cause of hypoxemia in patients with COPD. (c) 2005 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.rmed.2005.08.015
dc.identifier.endpage910en_US
dc.identifier.issn0954-6111
dc.identifier.issn1532-3064
dc.identifier.issue5en_US
dc.identifier.pmid16214323en_US
dc.identifier.scopus2-s2.0-33645894465en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage903en_US
dc.identifier.urihttps://doi.org/10.1016/j.rmed.2005.08.015
dc.identifier.urihttps://hdl.handle.net/11616/94359
dc.identifier.volume100en_US
dc.identifier.wosWOS:000237093500019en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherW B Saunders Co Ltden_US
dc.relation.ispartofRespiratory Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectpatent foramen ovaleen_US
dc.subjectCOPDen_US
dc.subjectprevalenceen_US
dc.subjectclinical significanceen_US
dc.titlePrevalence and clinical significance of a patent foramen ovate in patients with chronic obstructive pulmonary diseaseen_US
dc.typeArticleen_US

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