Novel morpholine liganded Pd-based N-heterocyclic carbene complexes: Synthesis, characterization, crystal structure, antidiabetic and anticholinergic properties

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dc.authoridsağlamtaş, rüya/0000-0002-4400-2302
dc.authoridAygün, Muhittin/0000-0001-9670-9062
dc.authoridAktaş, Aydın/0000-0001-8496-6782
dc.authoridGulcin, ilhami/0000-0001-5993-1668
dc.authoridTaslimi, Parham/0000-0002-3171-0633
dc.authorwosidGök, Yetkin/AAA-5669-2021
dc.authorwosidsağlamtaş, rüya/ABC-8186-2021
dc.authorwosidAygün, Muhittin/P-3605-2019
dc.authorwosidBarut Celepci, Duygu/M-6189-2017
dc.authorwosidAktaş, Aydın/J-6194-2019
dc.authorwosidGulcin, ilhami/F-1428-2014
dc.authorwosidkaya, rüya/AAB-2401-2021
dc.contributor.authorAktas, Aydin
dc.contributor.authorCelepci, Duygu Barut
dc.contributor.authorKaya, Ruya
dc.contributor.authorTaslimi, Parham
dc.contributor.authorGok, Yetkin
dc.contributor.authorAygun, Muhittin
dc.contributor.authorGulcin, Ilhami
dc.date.accessioned2024-08-04T20:45:37Z
dc.date.available2024-08-04T20:45:37Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThis study involves the synthesis of novel N-heterocyclic carbene (NHC)PdX2(morpholine) complexes (1a-i). These Pd-based complexes are synthesized from pyridine enhanced precatalyst preparation stabilization and initiation (PEPPSI) complexes and morpholine. The new complexes were characterized by spectroscopy (IR, H-1 and C-13 NMR) techniques. Also, the crystal structures of lb and if were obtained by utilizing the single-crystal X-ray diffraction method. The synthesized compounds in this study were investigated for their inhibition action against equin serum butyrylcholinesterase (BChE) and Electrophorus electricus acetylcholinesterase (AChE) as the capability drug aims for Alzheimer's disease (AD). These novel morpholine liganded Pd-based N-heterocyclic complexes were good inhibitors of BChE, alpha-glycosidase, cytosolic carbonic anhydrase I and II isoforms (hCA I and II), and AChE, with K-i values in the range of 10.77 +/- 1.01-45.86 +/- 5.65 mu M for hCA I, 25.42 +/- 5.18-57.82 +/- 3.01 mu M for hCA II, 12.26 +/- 3.32-50.36 +/- 6.19 mu M for a-glycosidase, 9.97 +/- 1.26-60.75 +/- 15.98 M for BChE, and 10.28 1.55-30.12 3.22 M for AChE. The inhibition of the alpha-glycosidase enzyme, an important carbohydrate hydrolyzing catalyst, could be used as one of the efficient methodologies in both treating and preventing diabetes by controlling the suppressing postprandial hyperglycemia and postprandial glucose amounts. (C) 2018 Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipDokuz Eylul University [2010.KB.FEN.13]en_US
dc.description.sponsorshipThe authors acknowledge Dokuz Eylul University for the use of the Oxford Rigaku Xcalibur Eos Diffractometer (purchased under University Research Grant No: 2010.KB.FEN.13). The authors thank the Inonu University, Faculty of Science, Department of Chemistry for the spectroscopy and elemental analysis characterization of compounds.en_US
dc.identifier.doi10.1016/j.poly.2018.11.048
dc.identifier.endpage354en_US
dc.identifier.issn0277-5387
dc.identifier.scopus2-s2.0-85059070420en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage345en_US
dc.identifier.urihttps://doi.org/10.1016/j.poly.2018.11.048
dc.identifier.urihttps://hdl.handle.net/11616/98587
dc.identifier.volume159en_US
dc.identifier.wosWOS:000458228000040en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofPolyhedronen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectN-Heterocyclic carbene complexen_US
dc.subjectMorpholineen_US
dc.subjectX-ray diffractionen_US
dc.subjectCarbonic anhydraseen_US
dc.subjectEnzyme inhibitionen_US
dc.titleNovel morpholine liganded Pd-based N-heterocyclic carbene complexes: Synthesis, characterization, crystal structure, antidiabetic and anticholinergic propertiesen_US
dc.typeArticleen_US

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