The investigation of the antioxidative properties of the novel synthetic organoselenium compounds in some rat tissues

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dc.authoridYılmaz, İsmet/0000-0002-7204-1050
dc.authoridSelamoglu, Zeliha/0000-0001-9056-6435
dc.authorwosidYılmaz, İsmet/P-9976-2015
dc.authorwosidGök, Yetkin/AAA-5669-2021
dc.authorwosidYılmaz, ismet/AAG-8946-2019
dc.authorwosidÖzdemir, İlknur/AAA-6216-2021
dc.contributor.authorTalas, Zeliha Selamoglu
dc.contributor.authorOzdemir, Ilknur
dc.contributor.authorYilmaz, Ismet
dc.contributor.authorGok, Yetkin
dc.contributor.authorOrun, Ibrahim
dc.date.accessioned2024-08-04T20:30:48Z
dc.date.available2024-08-04T20:30:48Z
dc.date.issued2008
dc.departmentİnönü Üniversitesien_US
dc.description.abstractDMBA (7,12-dimethylbenz[a]anthracene) is a polycyclic aromatic hydrocarbon (PAH) known to cause tumors in rats. Selenium is an essential element with physiological nonenzymatic antioxidant properties. Because of the health problems induced by many environmental pollutants, many efforts have been undertaken in evaluating the relative antioxidant potential of selenium and synthetic organoselenium compounds. In this study, adult female Wistar rats were treated with DMBA and the novel organoselenium compounds (1-isopropyl-3-methylbenzimidazole-2-selenone [Sel] and 1,3di-p-methoxybenzylpyrimidine-2-selenone [Sell]) in the determined doses. The protective effects of novel synthetic organoselenium compounds (Sel and Sell) against DMBA-induced changes in superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) activities and total glutathione (GSH) and malonedialdehyde (MDA) levels of rat heart and brain were investigated. It was determined that Sel and Sell fully or partially restored enzyme activity. It was also found that lipid peroxidation was also decreased in Sel and Sell treated groups. Consequently, it was determined that novel synthetic organoselenium compounds (Sel and Sell) provided protection of antioxidant activity, and protection against lipid peroxidation measured as MDA in Sel and Sell treated groups was provided by novel synthesized organoselenium compounds. The ability of the organoselenium compounds to prevent oxidative damage induced by DMBA in rats was rationalized.en_US
dc.identifier.doi10.3181/0707-RM-191
dc.identifier.endpage579en_US
dc.identifier.issn1535-3702
dc.identifier.issn1535-3699
dc.identifier.issue5en_US
dc.identifier.pmid18375834en_US
dc.identifier.scopus2-s2.0-43249095483en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage575en_US
dc.identifier.urihttps://doi.org/10.3181/0707-RM-191
dc.identifier.urihttps://hdl.handle.net/11616/94528
dc.identifier.volume233en_US
dc.identifier.wosWOS:000255321300011en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofExperimental Biology and Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDMBAen_US
dc.subjectbrainen_US
dc.subjecthearten_US
dc.subjectoxidative stressen_US
dc.subjectraten_US
dc.subjectsynthetic organoselenium compoundsen_US
dc.titleThe investigation of the antioxidative properties of the novel synthetic organoselenium compounds in some rat tissuesen_US
dc.typeArticleen_US

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