Metabolomics analysis of placental tissue obtained from patients with fetal growth restriction

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dc.authoridKaraer, Abdullah/0000-0002-2010-6211
dc.authoridDogan, Berat/0000-0003-4810-1970
dc.authorwosidKaraer, Abdullah/ABI-4667-2020
dc.authorwosidDogan, Berat/AAJ-7288-2020
dc.contributor.authorKaraer, Abdullah
dc.contributor.authorMumcu, Akin
dc.contributor.authorArda, Senem
dc.contributor.authorTuncay, Gorkem
dc.contributor.authorDogan, Berat
dc.date.accessioned2024-08-04T20:51:38Z
dc.date.available2024-08-04T20:51:38Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim The aim of this study was to determine whether there was a difference in placental metabolite profiles between patients with fetal growth restriction (FGR) and healthy controls. Methods The study included 10 patients with FGR diagnosis with 14 healthy controls with both matched maternal age and body mass index. H-1 HR-MAS NMR spectroscopy data obtained from placental tissue samples of patients with FGR and healthy control group were analyzed with bioinformatics methods. The obtained results of metabolite levels were further validated with the internal standard (IS) quantification method. Results Principal component analysis (PCA) and the partial least squares discriminant analysis (PLS-DA) score plots obtained with the multivariate statistical analysis of preprocessed spectral data shows a separation between the samples from patients with FGR and healthy controls. Bioinformatics analysis results suggest that the placental levels of lactate, glutamine, glycerophosphocholine, phosphocholine, taurine, and myoinositol are increased in patients with FGR compared to the healthy controls. Conclusions Placental metabolic dysfunctions are a common occurrence in FGR.en_US
dc.description.sponsorshipScientific Research Projects Unit of Inonu University [TSG-2018-798]en_US
dc.description.sponsorshipThe authors would like to thank all subjects who have agreed to participate in the study, as well as the staff at the Inonu University, Department of Obstetrics and Gynecology. The study was supported by Scientific Research Projects Unit of Inonu University (under grant number TSG-2018-798).en_US
dc.identifier.doi10.1111/jog.15173
dc.identifier.endpage929en_US
dc.identifier.issn1341-8076
dc.identifier.issn1447-0756
dc.identifier.issue4en_US
dc.identifier.pmid35104920en_US
dc.identifier.scopus2-s2.0-85123922098en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage920en_US
dc.identifier.urihttps://doi.org/10.1111/jog.15173
dc.identifier.urihttps://hdl.handle.net/11616/100454
dc.identifier.volume48en_US
dc.identifier.wosWOS:000749263800001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Obstetrics and Gynaecology Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectfetal growth restrictionen_US
dc.subjectmetabolomicsen_US
dc.subjectNMRen_US
dc.subjectplacentaen_US
dc.titleMetabolomics analysis of placental tissue obtained from patients with fetal growth restrictionen_US
dc.typeArticleen_US

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