In vitro cytotoxic activities of new silver and PEPPSI palladium N-heterocyclic carbene complexes derived from benzimidazolium salts

Basit Öğe Kaydı
dc.authoridUpadhyay, Parth/0000-0003-2729-2093
dc.authoridAkkoc, Senem/0000-0002-1260-9425
dc.authoridKayser, Veysel/0000-0003-1310-9534
dc.authorwosidGök, Yetkin/AAA-5669-2021
dc.authorwosidAkkoç, Senem/AAN-1478-2021
dc.authorwosidKayser, Veysel/HKN-5249-2023
dc.authorwosidİLHAN, İLHAN ÖZER/AAN-1469-2021
dc.contributor.authorAkkoc, Senem
dc.contributor.authorIlhan, Ilhan Ozer
dc.contributor.authorGok, Yetkin
dc.contributor.authorUpadhyay, Parth J.
dc.contributor.authorKayser, Veysel
dc.date.accessioned2024-08-04T20:41:46Z
dc.date.available2024-08-04T20:41:46Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractNew benzimidazolium salts (2, 3) and their silver (4, 5) and palladium (6, 7) N-heterocyclic carbene (Ag-and Pd-NHC) complexes were designed, synthesized and structurally characterized by NMR (H-1 and C-13), IR, HRMS and UV-Vis spectroscopic methods. All the synthesized compounds were tested in human colon cancer (DLD-1), breast cancer (MDA-MB-231) and embryonic kidney (HEK 293T) (non-cancerous) cell lines for in vitro cytotoxicity. Compound 4 specifically showed low IC50 values for these cell lines (IC50 values 12.41 +/- 2.89, 11.98 +/- 2.52 and 4.21 +/- 1.74 mu mol/L in DLD-1, MDA-MB-231 and HEK 293T cell lines, respectively). The Pd-NHC complexes (6, 7) did not exhibit cytotoxic activity (IC50 values > 200 in DLD-1, MDA-MB-231, HEK 293T cell lines). Therefore, Ag-NHC complexes can be further investigated as potential anticancer agents. (C) 2016 Elsevier B. V. All rights reserved.en_US
dc.description.sponsorshipTUBITAK [1059B141400496]; Erciyes University Research Fund [FDK-2014-5091]; Faculty of Pharmacy at The University of Sydneyen_US
dc.description.sponsorshipWe would like to thank Dr. Fanfan Zhou, Dr. Binh Pham and Dr. Byung Kim for donating cell lines. We would also like to thank Monira Haque for critical reading of the manuscript and Dr. Ramin Rohanizadeh for valuable discussions. This study was financially supported by TUBITAK (1059B141400496), Erciyes University Research Fund (FDK-2014-5091) and the Faculty of Pharmacy at The University of Sydney.en_US
dc.identifier.doi10.1016/j.ica.2016.05.001
dc.identifier.endpage81en_US
dc.identifier.issn0020-1693
dc.identifier.issn1873-3255
dc.identifier.scopus2-s2.0-84968912307en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage75en_US
dc.identifier.urihttps://doi.org/10.1016/j.ica.2016.05.001
dc.identifier.urihttps://hdl.handle.net/11616/97327
dc.identifier.volume449en_US
dc.identifier.wosWOS:000376521700011en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Science Saen_US
dc.relation.ispartofInorganica Chimica Actaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectN-heterocyclic carbene complexesen_US
dc.subjectBenzimidazolium saltsen_US
dc.subjectCytotoxic activityen_US
dc.subjectDLD-1en_US
dc.subjectMDA-MB-231en_US
dc.subjectHEK-293Ten_US
dc.titleIn vitro cytotoxic activities of new silver and PEPPSI palladium N-heterocyclic carbene complexes derived from benzimidazolium saltsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu