Early therapeutic plasma exchange may improve treatment outcomes in severe acute toxic Hepatitis

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dc.authoridBİÇİM, SOYKAN/0000-0001-7498-344X
dc.authoridGozukara Bag, Harika Gozde/0000-0003-1208-4072
dc.authoridYildirim, Oguzhan/0000-0001-8254-0104
dc.authoridPolat, Alaadin/0000-0002-6920-3856
dc.authoridSARICI, Ahmet/0000-0002-5916-0119
dc.authoridKAYA, Emin/0000-0001-8605-8497
dc.authoriderdogan, mehmet ali/0000-0002-1713-5695
dc.authorwosidBİÇİM, SOYKAN/ACZ-6163-2022
dc.authorwosidGozukara Bag, Harika Gozde/ABG-7588-2020
dc.authorwosidYildirim, Oguzhan/ABI-8174-2020
dc.authorwosidPolat, Alaadin/AAA-7171-2021
dc.authorwosidSARICI, Ahmet/ABI-7512-2020
dc.authorwosidKAYA, Emin/W-2951-2017
dc.authorwosiderdogan, mehmet ali/ABI-4675-2020
dc.contributor.authorBerber, Ilhami
dc.contributor.authorCagin, Yasir Furkan
dc.contributor.authorErdogan, Mehmet Ali
dc.contributor.authorAtaman, Engin
dc.contributor.authorGozukara, Harika
dc.contributor.authorErkurt, Mehmet Ali
dc.contributor.authorYildirim, Oguzhan
dc.date.accessioned2024-08-04T20:50:41Z
dc.date.available2024-08-04T20:50:41Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground and objectives: Acute toxic hepatitis can result in a different clinical course from a completely curable disease to subacute hepatitis, chronic hepatitis, and fulminant hepatitis failure, which is quite mortal. For this purpose, therapeutic plasma exchange (TPE) can be used for improving treatment outcomes by reducing the harmful substances caused with and/or without liver function in acute toxic hepatitis. We aimed to evaluate treatment outcomes in severe acute toxic hepatitis patients who applied early TPE procedure. Materials and Methods: A total of 335 patients who received TPE between 2010-2021 were retrospectively screened and 59 (male/female, 30/29; min/max-age, 22-84) patients with acute toxic hepatitis who underwent TPE in the first 24 h were included in the study. TPE was performed in patients who had high total bilirubin level (>10 mg/dL). Laboratory parameters of the patients before and after the TPE procedure, number of patients developed complications of acute toxic hepatitis and mortality rates were evaluated for effectiveness of TPE. Results: Acute toxic hepatitis was associated with hepatotoxic drugs in 44 (74.5 %), herbal medication 6 (10.2 %), mushroom poisoning 6 (10.2 %) and with substance abuse 3 (5.1 %) in patients. When the patients were compared based on INR, liver function tests, ammonia, lactate and Model For End-Stage Liver Disease (MELD) score at baseline, 48 h after TPE (independently of TPE number) and before final state a statistically significant decrease was observed in all parameters (p < 0.05). Fifty three (90 %) of patients improved without complications, the remaining 6 (10 %) patients were diagnosed with fulminant hepatitis. All these remaining patients died before liver transplantation (LTx) could be performed. Conclusion: TPE is a safe, tolerable therapy option and early TPE may improve treatment outcomes in severe acute toxic hepatitis.en_US
dc.identifier.doi10.1016/j.transci.2021.103250
dc.identifier.issn1473-0502
dc.identifier.issn1878-1683
dc.identifier.issue5en_US
dc.identifier.pmid34666895en_US
dc.identifier.scopus2-s2.0-85114819935en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1016/j.transci.2021.103250
dc.identifier.urihttps://hdl.handle.net/11616/100202
dc.identifier.volume60en_US
dc.identifier.wosWOS:000697004600020en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofTransfusion and Apheresis Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTherapeutic plasma exchangeen_US
dc.subjectSevere acute toxic hepatitisen_US
dc.subjectFulminant liver failureen_US
dc.titleEarly therapeutic plasma exchange may improve treatment outcomes in severe acute toxic Hepatitisen_US
dc.typeArticleen_US

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