Effect of extracorporeal photopheresis on survival in acute graft versus host disease

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dc.authoridSARICI, Ahmet/0000-0002-5916-0119
dc.authoridKAYA, Emin/0000-0001-8605-8497
dc.authoridYagin, Fatma Hilal/0000-0002-9848-7958
dc.authoridBİÇİM, SOYKAN/0000-0001-7498-344X
dc.authoridBERBER, Ilhami/0000-0003-3312-8476
dc.authoridERKURT, MEHMET ALI/0000-0002-3285-417X
dc.authoridCIRIK, SALIH/0000-0002-1368-7919
dc.authorwosidSARICI, Ahmet/ABI-7512-2020
dc.authorwosidKAYA, Emin/W-2951-2017
dc.authorwosidYagin, Fatma Hilal/ABI-8066-2020
dc.authorwosidBİÇİM, SOYKAN/ACZ-6163-2022
dc.authorwosidBERBER, Ilhami/ABI-6231-2020
dc.contributor.authorKaya, Ahmet
dc.contributor.authorErkurt, Mehmet Ali
dc.contributor.authorKuku, Irfan
dc.contributor.authorKaya, Emin
dc.contributor.authorBerber, Ilhami
dc.contributor.authorBicim, Soykan
dc.contributor.authorHidayet, Emine
dc.date.accessioned2024-08-04T20:54:30Z
dc.date.available2024-08-04T20:54:30Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Extracorporeal photopheresis (ECP) is the main non-pharmacological approach accompanying systemic medical treatments in steroid-resistant acute or chronic graft versus host disease. The study aimed to examine the effect of ECP on survival in acute graft versus host disease (aGVHD).Methods: A total of 35 patients who were followed up in the adult hematology clinic of Inonu University Turgut ozal Medical Center for aGVHD were included in the study. Stem cell transplantation and ECP application parameters that may affect the survival of the patients were examined.Results: In aGVHD using ECP, the degree of involvement affects survival. Involvements with a clinical and laboratory score (Glucksberg system) of 2 and above significantly reduced survival. The duration of ECP use is associated with survival. Especially, 45 days and longer use increases survival (hazard ratio, P-value <.05). The duration of steroid use was found to be effective in survival in aGVHD (P < .001). ECP administration day (P = .003), duration of steroid use (P < .001), duration of ECP use (P = .001), and grade of aGVHD (P < .001) affect survival.Conclusion: ECP use is effective in survival in patients with aGVHD score =2. In patients with aGVHD, especially the use of 45 days and longer has a positive effect on survival. The duration of steroid use is associated with survival in aGVHD.en_US
dc.identifier.doi10.1002/jca.22071
dc.identifier.issn0733-2459
dc.identifier.issn1098-1101
dc.identifier.pmid37421294en_US
dc.identifier.scopus2-s2.0-85164591558en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1002/jca.22071
dc.identifier.urihttps://hdl.handle.net/11616/101464
dc.identifier.wosWOS:001025476300001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Clinical Apheresisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectacute graft versus host diseaseen_US
dc.subjectextracorporeal photopheresisen_US
dc.subjectsurvivalen_US
dc.titleEffect of extracorporeal photopheresis on survival in acute graft versus host diseaseen_US
dc.typeArticleen_US

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