Dry Mouth Caused by Facial Nerve Ischemia due to Subarachnoid Hemorrhage: An Experimental Study

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dc.authoridPAŞAHAN, RAMAZAN/0000-0002-3221-1422
dc.authorwosidPAŞAHAN, RAMAZAN/AAB-3576-2021
dc.contributor.authorPasahan, Ramazan
dc.contributor.authorYardim, Ahmet
dc.contributor.authorKaradag, Mehmet Kursat
dc.contributor.authorAlpaslan, Aslihan
dc.contributor.authorAydin, Mehmet Dumlu
dc.date.accessioned2024-08-04T20:50:33Z
dc.date.available2024-08-04T20:50:33Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractOBJECTIVE: Parasympathetic network damage results in facial nerve damage, sublingual ganglion degeneration, sublingual gland dysfunction, and dry mouth. In this study, subarachnoid hemorrhage (SAH) was considered to be the cause of dry mouth. METHODS: We assessed 23 hybrid rabbits, including 5 control (group 1, Control). One milliliter of serum saline was injected into the cisterna magna of 5 animals (group 2). SAH was induced by injecting 1 mL of autologous blood into the cisterna magna of 13 animals (group 3). The animals were killed after 3 weeks of induction. The animals' sublingual ganglion and sublingual gland were excised for histopathological examination. The number of degenerated cells in the sublingual ganglion, secretory vesicles, and secretory granules in the sublingual gland that contain salivary components were estimated using Sequential Window Acquisition of All Theoretical Mass Spectra data analysis. The values were compared by the Mann-Whitney U-test. RESULTS: The numbers of secretory vesicles in the sublingual gland were 5.3 +/- 1.1 x 10(3) (group 1), 4.23 +/- 0.45 x 10(3) (group 2), and 1.56 +/- 0.22 x 10(3) (group 3); the numbers of secretory vesicles containing saliva in the sublingual gland were 324 +/- 12.18 (group 1), 263 +/- 36.23 (group 2), and 114 +/- 23.14 (group 3); and the numbers of degenerated cells in the sublingual ganglion were 11 +/- 3/mm(3) (group 1), 98.43 +/- 15.54/mm(3) (group 2), and 346 +/- 12.28/mm(3) (group 3) (P < 0.05). CONCLUSIONS: Clinical findings in infection and diseases such as Sjogren syndrome, aseptic meningitis, and SAH are similar. However, until now, SAH has not been demonstrated experimentally to cause dry mouth. Discovering that SAH might cause dry mouth might prevent unnecessary use of antibiotics and decrease morbidity due to the wrong or late diagnosis.en_US
dc.description.sponsorshipAtaturk University Scientific Research Projects (Bilimsel Arasxtirma Projeleri [BAP])en_US
dc.description.sponsorshipConflict of interest statement: This research was funded by the Ataturk University Scientific Research Projects (Bilimsel Arasxtirma Projeleri [BAP]).en_US
dc.identifier.doi10.1016/j.wneu.2021.07.072
dc.identifier.endpageE494en_US
dc.identifier.issn1878-8750
dc.identifier.issn1878-8769
dc.identifier.pmid34311137en_US
dc.identifier.scopus2-s2.0-85112583008en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpageE488en_US
dc.identifier.urihttps://doi.org/10.1016/j.wneu.2021.07.072
dc.identifier.urihttps://hdl.handle.net/11616/100132
dc.identifier.volume154en_US
dc.identifier.wosWOS:000705004400038en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofWorld Neurosurgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDry mouthen_US
dc.subjectSubarachnoid hemorrhageen_US
dc.subjectSublingual glanden_US
dc.titleDry Mouth Caused by Facial Nerve Ischemia due to Subarachnoid Hemorrhage: An Experimental Studyen_US
dc.typeArticleen_US

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