The effect of COVID-19 on nasal mucociliary clearance

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dc.authoridAslan, Mehmet/0000-0002-0707-9984
dc.authoridAslan, Mehmet/0000-0002-0707-9984
dc.authorwosidAslan, Mehmet/AED-5913-2022
dc.authorwosidAslan, Mehmet/ABI-8036-2020
dc.contributor.authorOzturk, Ebru Ozer
dc.contributor.authorAslan, Mehmet
dc.contributor.authorBayindir, Tuba
dc.date.accessioned2024-08-04T20:51:46Z
dc.date.available2024-08-04T20:51:46Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground The impacts of coronavirus disease-2019 (COVID-19) on nasal mucociliary clearance (MCC) have shown conflicting results. Objectives The aim of this study was to determine whether COVID-19 infections affect nasal mucociliary activity using the saccharin test to measure nasal MCC time. Material and Methods This prospective comparative investigation included 25 patients with COVID-19 infection and 25 healthy controls. The nasal MCC time was assessed using the saccharin test. Saccharin test was applied to COVID-19 patients between the 10th and 20th days of COVID-19 test positivity. Patients admitted to the otolaryngology outpatient clinic with non-nasal symptoms and no history of COVID-19 infection served as the control subjects. Results Age, gender distribution, smoking, and alcohol usage, and the existence of other systemic disorders had no statistically significant differences between the groups (p = 0.25, p = 0.77, p = 1.00, p = 0.28, p = 0.54, respectively). The COVID-19 group had a mean nasal MCC time of 12.00 +/- 2.51 min, compared to 9.77 +/- 2.51 min in the control group. The nasal MCC time in the COVID-19 group was statistically significantly longer (p = 0.043). Conclusions and Significance The COVID-19 infection negatively affects mucociliary activity and causes prolongation of MCC. As the nasal defense mechanism weakens in the early period after COVID-19 infection, susceptibility to respiratory infections may occur.en_US
dc.identifier.doi10.1080/00016489.2022.2048072
dc.identifier.endpage332en_US
dc.identifier.issn0001-6489
dc.identifier.issn1651-2251
dc.identifier.issue3-4en_US
dc.identifier.pmid35294841en_US
dc.identifier.scopus2-s2.0-85126705833en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage329en_US
dc.identifier.urihttps://doi.org/10.1080/00016489.2022.2048072
dc.identifier.urihttps://hdl.handle.net/11616/100547
dc.identifier.volume142en_US
dc.identifier.wosWOS:000769867800001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofActa Oto-Laryngologicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCOVID-19en_US
dc.subjectmucociliary clearanceen_US
dc.subjectrespiratory infectionen_US
dc.subjectsaccharin testen_US
dc.titleThe effect of COVID-19 on nasal mucociliary clearanceen_US
dc.typeArticleen_US

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