Investigation of the antitumor effects of anti-inflammatory desloratadine and trimebutine on different types of human cancer cells: An in vitro study

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dc.contributor.authorÖzkaya, Semiha Nur
dc.contributor.authorKeskin, Tuba
dc.contributor.authorTekin, Çiğdem
dc.contributor.authorTekin, Suat
dc.contributor.authorBeytur, Ali
dc.date.accessioned2024-08-04T19:42:43Z
dc.date.available2024-08-04T19:42:43Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim: Inflammation is a process associated with the development and progression of cancer. Desloratadine (DES) and Trimebutin (TMB) are anti-inflammatory agents used in the treatment of various diseases. This study aimed to investigate the antitumor effects of DES and TMB, which exhibit anti-inflammatory effects, on different human cancer cell lines. Materials and Methods: In this study, human prostate (LNCaP), ovarian (A2780), breast (MCF-7) and colon cancer (Caco-2) cell lines were treated with DES and TMB at concentrations of 1, 5, 25, 50 and 100 µM. Cells were treated with the compounds for 6, 12, and 24 hours, and the change in cell viability was determined using the 3- (4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The inhibitory concentration 50 (LogIC50) values of the compounds were calculated using GraphPad Prism 8 software based on cell viability results. The genotoxic effects of the compounds on cells were determined using the comet assay. Group comparisons were performed using the Kruskal-Wallis H test and p<0.05 was considered significant. Results: Exposure of LNCaP, A2780, MCF-7, and Caco-2 cells to DES and TMB agents for 6, 12 and 24 hours significantly reduced cell viability (p<0.05). According to the comet assay results, DES and TMB caused significant DNA damage in the cell lines (p<0.05). Conclusion: The study results demonstrate that DES and TMB, which have anti inflammatory effects, exert cytotoxic effects by inducing DNA damage in cancer cells.en_US
dc.identifier.doi10.5455/annalsmedres.2023.05.122
dc.identifier.endpage732en_US
dc.identifier.issn2636-7688
dc.identifier.issue6en_US
dc.identifier.startpage727en_US
dc.identifier.trdizinid1189100en_US
dc.identifier.urihttps://doi.org/10.5455/annalsmedres.2023.05.122
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1189100
dc.identifier.urihttps://hdl.handle.net/11616/88619
dc.identifier.volume30en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofAnnals of Medical Researchen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleInvestigation of the antitumor effects of anti-inflammatory desloratadine and trimebutine on different types of human cancer cells: An in vitro studyen_US
dc.typeArticleen_US

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