Expression of Endometrial Receptivity Genes Increase After Myomectomy of Intramural Leiomyomas not Distorting the Endometrial Cavity

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dc.authoridOTLU, BARIS/0000-0002-6220-0521
dc.authoridUnlu, Mehmet Cihat/0000-0001-5507-3993
dc.authorwosidOTLU, BARIS/ABI-5532-2020
dc.authorwosidUnlu, Mehmet Cihat/Q-5146-2018
dc.contributor.authorUnlu, Cihat
dc.contributor.authorCelik, Onder
dc.contributor.authorCelik, Nilufer
dc.contributor.authorOtlu, Baris
dc.date.accessioned2024-08-04T20:41:35Z
dc.date.available2024-08-04T20:41:35Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThis study was designed to investigate whether endometrial receptivity genes are altered in infertile patients with intramural leiomyomas (IM) not distorting the endometrial cavity undergoing myomectomy. We measured endometrial HOXA-10, HOXA-11, LIF, ITGB3, and ITGAV messenger RNA (mRNA) expressions levels before and after myomectomy/metroplasty during mid-luteal phase in participants with IM, submucosal leiomyomas (SM), and septate uterus and fertile participants without fibroids. Initial endometrial sampling was obtained at the time of surgery, and second sampling was obtained 3 months after myomectomy/metroplasty. Expressions of each gene were evaluated using real-time reverse transcriptase polymerase chain reaction (RT-PCR). A trend toward decreased endometrial HOXA-10, HOXA-11, and ITGAV mRNA expression was detected in both SM and IM groups before myomectomy when compared to both fertile group and septate uterus. However, the differences failed to show statistical significance. After myomectomy of IM, we have detected 12.8-fold increase in endometrial HOXA-10 mRNA expression and 9.0-fold increase in endometrial HOXA-11 mRNA expression. This increase in endometrial HOXA-10 and 11 mRNA expression was significant. Accordingly, 2 patients having intramural fibroids greater than 5 cm were able to remain pregnant after myomectomy. Conversely, submucosal myomectomy did not cause any significant effect on endometrial receptivity markers. Likewise, all markers of endometrial receptivity remained unchanged after metroplasty. Myomectomy of IM have favorable effect on endometrial HOXA-10 and 11 mRNA expression.en_US
dc.description.sponsorshipTurkish German Gynecological Resarch and Education Foundationen_US
dc.description.sponsorshipThe author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was supported by the Turkish German Gynecological Resarch and Education Foundation.en_US
dc.identifier.doi10.1177/1933719115612929
dc.identifier.endpage41en_US
dc.identifier.issn1933-7191
dc.identifier.issn1933-7205
dc.identifier.issue1en_US
dc.identifier.pmid26507873en_US
dc.identifier.scopus2-s2.0-84959335697en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage31en_US
dc.identifier.urihttps://doi.org/10.1177/1933719115612929
dc.identifier.urihttps://hdl.handle.net/11616/97200
dc.identifier.volume23en_US
dc.identifier.wosWOS:000366647300004en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofReproductive Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectintramural leiomyomasen_US
dc.subjectsubmucosal leiomyomasen_US
dc.subjectseptate uterusen_US
dc.subjectmyomectomyen_US
dc.subjectimplantationen_US
dc.subjectendometrial receptivity genesen_US
dc.titleExpression of Endometrial Receptivity Genes Increase After Myomectomy of Intramural Leiomyomas not Distorting the Endometrial Cavityen_US
dc.typeArticleen_US

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