Evaluation of CD4/CD8 ratio in treatment follow-up of patients with HIV diagnois in an infection clinic

Basit Öğe Kaydı
dc.contributor.authorGezer, Yakup
dc.contributor.authorToplu, Sibel
dc.contributor.authorYüksel, Mustafa
dc.contributor.authorKöse, Adem
dc.contributor.authorMemişoğlu, Funda
dc.contributor.authorOzden, Mehmet
dc.contributor.authorBayindir, Yasar
dc.date.accessioned2024-08-04T19:42:42Z
dc.date.available2024-08-04T19:42:42Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAbstract Aim: Antiretroviral therapy (ART) regimens used in the treatment of HIV are assumed to suppress the virus in plasma indefinitely and restore CD4 lymphocyte count. There is increasing evidence that a reversed CD4/CD8 ratio is associated with immune dysfunction, even in patients who have achieved virological suppression with ART and have elevated CD4 lymphocytes. The CD4/CD8 ratio has emerged as a guiding marker as an indicator of immunoactivation in HIV-infected patients. It was aimed to evaluate the CD4/CD8 ratio of HIV-diagnosed patients at baseline and at follow-up after ART regimen. Materials and Methods: A total of 150 patients were included in the study by retrospectively scanning the CD4/CD8 ratio at the initial and 24th week of follow-up in patients who were diagnosed with HIV and started treatment in the Infectious Diseases and Clinical Microbiology Clinic of the Hospital of the Medical Faculty between 2011-2021. ART treatment regimens were divided into three groups as nucleoside reverse transcriptase inhibitor (NRTI)+protease inhibitor (PI), NRTI+non-nucleoside reverse transcriptase inhibitor (NNRTI) or NRTI+ integrase strand transfer inhibitor (INSTI). Results: A total of 150 patients were included in the study. While the initial CD4/CD8 ratio of the patients was 0.36, it increased to 0.61 at the 24th week of treatment. Among the 144 patients whose baseline values were CD4/CD8<1, the rate of the ones who achieved CD4/CD8?1 value at week 24 after ART regimens was found as 13.2% (19/144). It was observed that the CD4/CD8 ratio in the group receiving INSTI was higher (15.1%) than those of the other groups. The undetectable HIV RNA level after treatment was significantly mostly observed in the group, receiving the integrase-based regimen, with 77.1%. With effective ART, CD4/CD8 normalization is higher in individuals with high CD4 T cell counts before treatment. There was a significant increase in the CD4/CD8 ratio in all three ART regimen groups. However, most of the patients who achieved a CD4/CD8 ratio ?1 were in the INSTI-based ART group. Conclusion: The CD4/CD8 ratio may contribute to clinical evaluation in long-term follow-up as a marker of immunological response in individuals treated with a diagnosis of HIV.en_US
dc.identifier.doi10.5455/annalsmedres.2022.01.022
dc.identifier.endpage747en_US
dc.identifier.issn2636-7688
dc.identifier.issue7en_US
dc.identifier.startpage743en_US
dc.identifier.trdizinid1119457en_US
dc.identifier.urihttps://doi.org/10.5455/annalsmedres.2022.01.022
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1119457
dc.identifier.urihttps://hdl.handle.net/11616/88573
dc.identifier.volume29en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofAnnals of Medical Researchen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleEvaluation of CD4/CD8 ratio in treatment follow-up of patients with HIV diagnois in an infection clinicen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

TR-Dizin İndeksli Yayınlar Koleksiyonu