Evaluation of Oxidative Stress and Endothelial Dysfunction in COVID-19 Patients

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dc.contributor.authorBerber, Nurcan Kirici
dc.contributor.authorKurt, Osman
dc.contributor.authorGeckil, Ayseguel Altintop
dc.contributor.authorErdem, Mehmet
dc.contributor.authorKiran, Tugba Raika
dc.contributor.authorOtlu, Onder
dc.contributor.authorEcin, Seval Muzeyyen
dc.date.accessioned2026-04-04T13:31:00Z
dc.date.available2026-04-04T13:31:00Z
dc.date.issued2024
dc.departmentİnönü Üniversitesi
dc.description.abstractBackground and Objectives: Heat shock proteins (HSPs) are stress proteins. The endogenous nitric oxide (NO) synthase inhibitor asymmetric dimethyl arginine (ADMA) is a mediator of endothelial dysfunction. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus causes endothelial dysfunction and coagulopathy through severe inflammation and oxidative stress. Using these markers, we analyzed the prognostic value of serum ADMA and HSP-90 levels for early prediction of severe coronavirus disease (COVID-19) patients. Materials and Methods: A total of 76 COVID-19 patients and 35 healthy control subjects were included in this case-control study. COVID-19 patients were divided into two groups: mild and severe. Results: Serum ADMA and HSP-90 levels were significantly higher in the COVID-19 patients compared to the control subjects (p < 0.001). Additionally, serum ADMA and HSP-90 levels were determined to be higher in a statistically significant way in severe COVID-19 compared to mild COVID-19 (p < 0.001). Univariable logistic regression analysis revealed that ADMA and HSP-90, respectively, were independent predictors of severe disease in COVID-19 patients (ADMA (OR = 1.099, 95% CI = 1.048-1.152, p < 0.001) and HSP-90 (OR = 5.296, 95% CI = 1.719-16.316, p = 0.004)). When the cut-off value for ADMA was determined as 208.94 for the prediction of the severity of COVID-19 patients, the sensitivity was 72.9% and the specificity was 100% (AUC = 0.938, 95%CI = 0.858-0.981, p < 0.001). When the cut-off value for HSP-90 was determined as 12.68 for the prediction of the severity of COVID-19 patients, the sensitivity was 88.1% and the specificity was 100% (AUC = 0.975, 95% CI= 0.910-0.997, p < 0.001). Conclusions: Increased levels of Heat shock proteins-90 (HSP-90) and ADMA were positively correlated with increased endothelial damage in COVID-19 patients, suggesting that treatments focused on preventing and improving endothelial dysfunction could significantly improve the outcomes and reduce the mortality rate of COVID-19. ADMA and HSP-90 might be simple, useful, and prognostic biomarkers that can be utilized to predict patients who are at high risk of severe disease due to COVID-19.
dc.description.sponsorshipMalatya Turgut OEzal University Scientific Research Projects Unit [2021/5]
dc.description.sponsorshipThe current study was supported by Malatya Turgut OEzal University Scientific Research Projects Unit (Project no: 2021/5).
dc.identifier.doi10.3390/medicina60071041
dc.identifier.issn1010-660X
dc.identifier.issn1648-9144
dc.identifier.issue7
dc.identifier.orcid0000-0002-7701-7826
dc.identifier.orcid0000-0003-4164-3611
dc.identifier.orcid0000-0002-3724-0249
dc.identifier.pmid39064471
dc.identifier.scopus2-s2.0-85199900405
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/medicina60071041
dc.identifier.urihttps://hdl.handle.net/11616/108518
dc.identifier.volume60
dc.identifier.wosWOS:001278640700001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofMedicina-Lithuania
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectCOVID-19
dc.subjectendothelial dysfunction
dc.subjectoxidative stress
dc.subjectheat shock proteins
dc.titleEvaluation of Oxidative Stress and Endothelial Dysfunction in COVID-19 Patients
dc.typeArticle

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