Investigation of the risk factors in the development of radionecrosis in patients with brain metastases undergoing stereotactic radiotherapy

Basit Öğe Kaydı
dc.authoridGunbey, HP/0000-0001-5288-5590
dc.authoridIsik, Naciye/0000-0002-7444-5913
dc.authoridDOGAN, BEDRIYE/0000-0002-8726-3801
dc.authorid, HARUN/0000-0001-8579-9939
dc.authorwosidGunbey, HP/JAN-9081-2023
dc.authorwosidIsik, Naciye/HGF-1244-2022
dc.contributor.authorDogan, Bedriye
dc.contributor.authorDemir, Harun
dc.contributor.authorIsik, Naciye
dc.contributor.authorGunalp, Gun
dc.contributor.authorGunbey, Hediye Pinar
dc.contributor.authorYaprak, Gokhan
dc.date.accessioned2024-08-04T20:55:59Z
dc.date.available2024-08-04T20:55:59Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: To investigate the incidence, timing, and the factors predictors radionecrosis (RN) development in brain metastases (BMs) undergoing stereotactic radiotherapy (SRT). Methods: The study evaluated 245 BMs who exclusively received SRT between 2010 and 2020. RN was detected pathologically or radiologically. Results: The median of follow-up was 22.6 months. RN was detected in 18.4% of the metastatic lesions, and 3.3% symptomatic, 15.1% asymptomatic. The median time of RN was 22.8 months (2.5-39.5), and the rates at 6, 12, and 24 months were 16.8%, 41.4%, and 66%, respectively. Univariate analysis revealed that Graded Prognostic Assessment (P = .005), Score Index of Radiosurgery (P = .015), Recursive Partitioning Analysis (P = .011), the presence of primary cancer (P = .004), and localization (P = .048) significantly increased the incidence of RN. No significant relationship between RN and brain-gross tumour volume doses, planning target volume, fractionation, dose (P > .05). Multivariate analysis identified SIR > 6 (OR: 1.30, P = .021), primary of breast tumour (OR: 2.33, P = .031) and supratentorial localization (OR: 3.64, P = .025) as risk factors. Conclusions: SRT is used effectively in BMs. The incidence of RN following SRT is undeniably frequent. It was observed that the incidence rate increased as the follow-up period increased. We showed that brain-GTV doses are not predictive of RN development, unlike other publications. In study, a high SIR score and supratentorial localization were identified as factors that increased the risk of RN. Advances in knowledge: RN is still a common complication after SRT. Symptomatic RN is a significant cause of morbidity. The causes of RN are still not clearly identified. In many publications, brain dose and volumes have been found to be effective in RN. But, with this study, we found that brain dose volumes and fractionation did not increase the incidence of RN when brain doses were taken into account. The most important factor in the development of RN was found to be related to long survival after SRT.en_US
dc.identifier.doi10.1093/bjr/tqae051
dc.identifier.endpage1028en_US
dc.identifier.issn0007-1285
dc.identifier.issn1748-880X
dc.identifier.issue1157en_US
dc.identifier.pmid38426391en_US
dc.identifier.scopus2-s2.0-85192682538en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1022en_US
dc.identifier.urihttps://doi.org/10.1093/bjr/tqae051
dc.identifier.urihttps://hdl.handle.net/11616/101985
dc.identifier.volume97en_US
dc.identifier.wosWOS:001193588300001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherOxford Univ Pressen_US
dc.relation.ispartofBritish Journal of Radiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbrain metastasisen_US
dc.subjectradionecrosisen_US
dc.subjectstereotactic radiosurgeryen_US
dc.subjectstereotactic radiotherapyen_US
dc.titleInvestigation of the risk factors in the development of radionecrosis in patients with brain metastases undergoing stereotactic radiotherapyen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu