Neurological autoantibodies in drug-resistant epilepsy of unknown cause

Basit Öğe Kaydı
dc.contributor.authorTecellioglu, Mehmet
dc.contributor.authorKamisli, Ozden
dc.contributor.authorKamisli, Suat
dc.contributor.authorYucel, Fatma Ebru
dc.contributor.authorOzcan, Cemal
dc.date.accessioned2019-06-24T06:21:23Z
dc.date.available2019-06-24T06:21:23Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackgroundAutoimmune epilepsy is a rarely diagnosed condition. Recognition of the underlying autoimmune condition is important, as these patients can be resistant to antiepileptic drugs.AimsTo determine the autoimmune and oncological antibodies in adult drug-resistant epilepsy of unknown cause and identify the clinical, radiological, and EEG findings associated with these antibodies according to data in the literature.MethodsEighty-two patients with drug-resistant epilepsy of unknown cause were prospectively identified. Clinical features were recorded. The levels of anti-voltage-gated potassium channel complex (anti-VGKCc), anti-thyroid peroxidase (anti-TPO), anti-nuclear antibody (ANA), anti-glutamic acid decarboxylase (anti-GAD), anti-phospholipid IgG and IgM, anti-cardiolipin IgG and IgM, and onconeural antibodies were determined.ResultsSerum antibody positivity suggesting the potential role of autoimmunity in the aetiology was present in 17 patients with resistant epilepsy (22.0%). Multiple antibodies were found in two patients (2.6%). One of these patients (1.3%) had anti-VGKCc and ANA, whereas another (1.3%) had anti-VGKCc and anti-TPO. A single antibody was present in 15 patients (19.5%). Of the 77 patients finally included in the study, 4 had anti-TPO (5.2%), 1 had anti-GAD (1.3%), 4 had anti-VGKCc (5.2%) 8 had ANA (10.3%), and 2 had onconeural antibodies (2.6%) (1 patient had anti-Yo and 1 had anti-MA2/TA). The other antibodies investigated were not detected. EEG abnormality (focal), focal seizure incidence, and frequent seizures were more common in antibody-positive patients.ConclusionAutoimmune factors may be aetiologically relevant in patients with drug-resistant epilepsy of unknown cause, especially if focal seizures are present together with focal EEG abnormality and frequent seizures.en_US
dc.identifier.citationTecellioglu, M. Kamisli, O. Kamisli, S. Yucel, FE. Ozcan, C .(2018). Neurological autoantibodies in drug-resistant epilepsy of unknown cause. Cilt:187. Sayı:4. 1057-1063ss.en_US
dc.identifier.doi10.1007/s11845-018-1777-2en_US
dc.identifier.endpage1063en_US
dc.identifier.issue4en_US
dc.identifier.startpage1057en_US
dc.identifier.urihttps://hdl.handle.net/11616/12006
dc.identifier.volume187en_US
dc.language.isoenen_US
dc.publisherIrısh journal of medıcal scıenceen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGlutamıc-Acıd Decarboxylaseen_US
dc.subjectFocal Epılepsyen_US
dc.subjectAntıneuronal Autoantıbodıesen_US
dc.subjectAntınuclear Antıbodıesen_US
dc.subjectAntıthyroıd Antıbodıesen_US
dc.subjectIlae Commıssıonen_US
dc.subjectPrevalenceen_US
dc.subjectAntıcardıolıpınen_US
dc.titleNeurological autoantibodies in drug-resistant epilepsy of unknown causeen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
MAKALE DOSYASI.pdf
Boyut:
453.64 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Makale dosyası
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.71 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Tıp Fakültesi, Nöroloji Anabilim Dalı Koleksiyonu