Hemodynamic, Hepatorenal and Postoperative Effects of Desflurane-Fentanyl and Midazolam-Fentanyl Anaesthesia in Coronary Artery Bypass Surgery

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dc.authorscopusid8932188900
dc.authorscopusid34569135700
dc.authorscopusid55666804700
dc.authorscopusid7006384185
dc.authorscopusid7003586739
dc.authorscopusid7004486274
dc.contributor.authorBut A.K.
dc.contributor.authorDurmuş M.
dc.contributor.authorToprak H.I.
dc.contributor.authorÖztürk E.
dc.contributor.authorDemirbilek S.
dc.contributor.authorErsoy M.O.
dc.date.accessioned2024-08-04T20:02:10Z
dc.date.available2024-08-04T20:02:10Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this study, we aimed to compare the hemodynamic, hepatorenal and postoperative effects of desflurane-fentanyl and midazolam-fentanyl anaesthesia during coronary artery bypass surgery. Sixty patients undergoing elective coronary artery bypass surgery with ejection fraction of more than 45% were included in the study. Patients were randomly divided into two groups as desflurane (Group D, n=30) and midazolam (Group M, n=30). Anaesthesia was induced with etomidate, 0.2 mg kg-1 and fentanyl, 5 ?g kg -1 in Group D and with midazolam, 0.1-0.3 mg kg-1 and fentanyl, 5 ?g kg-1 in Group M. For the maintenance of anaesthesia; desflurane, 2-6% and fentanyl, 15-25 ?g kg-1 were given in group D and infusion of midazolam at a rate of 0.1-0.5 mg kg -1 hr-1 and fentanyl at a rate of 15-25 ?g kg -1 were used in group M. Heart rate, mean arterial blood pressure, central venous pressure, mean pulmonary artery pressure, pulmonary capillary wedge pressure, cardiac index, systemic vascular resistance index, pulmonary vascular resistance index, left ventricle stroke work index and right ventricle stroke work index were measured before induction (t0), after induction (t1), after intubation (t2), after incision (t3), after sternotomy (t4), before cardiopulmonary bypass (t5), after protamine administration (t6) and at the end of the surgery (t7). Blood samples were taken to measure total bilirubine, aspartate amino transferase, gamma glutamyl transferase, lactate dehydrogenase, alkalane phosphatase, creatinine and blood urea nitrogen just before induction and at the 1st 4th and 14th days of postoperative period. In conclusion; intraoperative hemodynamic responses were similar in both of the groups and transient hepatic and renal dysfunction were observed in the postoperative period in both groups. The extubation and ICU discharge time were found to be shorter in the desflurane-fentanyl group.en_US
dc.identifier.endpage129en_US
dc.identifier.issn1304-0871
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-2342536885en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage120en_US
dc.identifier.urihttps://hdl.handle.net/11616/91450
dc.identifier.volume32en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.relation.ispartofTurk Anesteziyoloji ve Reanimasyon Dernegi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCoronary artery bypass graftingen_US
dc.subjectDesfluraneen_US
dc.subjectKidneyen_US
dc.subjectLiveren_US
dc.subjectMidazolamen_US
dc.titleHemodynamic, Hepatorenal and Postoperative Effects of Desflurane-Fentanyl and Midazolam-Fentanyl Anaesthesia in Coronary Artery Bypass Surgeryen_US
dc.title.alternativeKoroner Arter Cerrahisinde Desfluran-Fentanil ve Midozolam-Fentanil Anestezisinin Hemodinamik, Hepato-Renal ve Postoperatif Etkilerien_US
dc.typeArticleen_US

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