Comparison of the selenium level with GSH-Px activity in the liver of mice treated with 7,12 DMBA

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dc.authoridBatcioglu, Kadir/0000-0001-6663-2287
dc.authorwosidKARATAS, Fikret/W-3340-2018
dc.authorwosid/ABG-9766-2020
dc.authorwosidBatcioglu, Kadir/Q-2424-2015
dc.contributor.authorBatcioglu, K
dc.contributor.authorOzturk, C
dc.contributor.authorKaragozler, A
dc.contributor.authorKaratas, F
dc.date.accessioned2024-08-04T20:12:21Z
dc.date.available2024-08-04T20:12:21Z
dc.date.issued2002
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this study, the relationship between selenium (Se) and glutathione peroxidase (GSHPx) levels was investigated in 7,12-dimethylbenz(a)anthracene (7,12-DMBA)-treated mouse liver. The potential mammary carcinogen 7,12-DMBA, was injected intraperitoneally (20 mg kg(-1) day(-1)) into 10-12 month old female mice. After 21 days of application the mice were sacrificed and GSHPx and Se levels of Liver homogenates were measured. Se and GSHPx levels in 7,12-DMBA-treated mice were significantly lower than those of controls (p<0.05). The control group exhibited 0.9 +/- 0.066 U mg(-1) protein and 0.86 +/- 0.058 p.p.m. levels of GSHPx and Se respectively. The 7,12-DMBA-treated group had significantly (p<0.05) decreased GSHPx and Se levels (0.42+/-0.062 U mg(-1) protein and 0.69+/-0.034 p.p.m. respectively). The results show a direct relationship between Se and GSHPx activity and a negative correlation between antioxidant capacity and existence of a carcinogen in metabolism. Copyright (C) 2001 John Wiley Sons, Ltd.en_US
dc.identifier.doi10.1002/cbf.958
dc.identifier.endpage118en_US
dc.identifier.issn0263-6484
dc.identifier.issn1099-0844
dc.identifier.issue2en_US
dc.identifier.pmid11979507en_US
dc.identifier.scopus2-s2.0-0036096676en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage115en_US
dc.identifier.urihttps://doi.org/10.1002/cbf.958
dc.identifier.urihttps://hdl.handle.net/11616/93377
dc.identifier.volume20en_US
dc.identifier.wosWOS:000175598700008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofCell Biochemistry and Functionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSeen_US
dc.subjectGSH-Pxen_US
dc.subject7,12-DMBAen_US
dc.titleComparison of the selenium level with GSH-Px activity in the liver of mice treated with 7,12 DMBAen_US
dc.typeArticleen_US

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