Circadian rhythm in mammals: time to eat & time to sleep

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dc.authorwosidGüldür, Tayfun/AAA-7088-2021
dc.contributor.authorGuldur, Tayfun
dc.contributor.authorOtlu, Husniye Gul
dc.date.accessioned2024-08-04T20:42:46Z
dc.date.available2024-08-04T20:42:46Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractCircadian rhythm is defined as rhythmic fluctuations in physiological processes which enable living organisms to make necessary arrangements for upcoming changes in the environment thereby optimizing their metabolism. Mammalian circadian clock consists of feedback(negative) and feedforward (positive) loops consisting of transcription, translation and posttranslational events. It is believed that there are two kinds of clock functioning in the body. The master clock residing in hypothalamus oscillating in conjunction with light/dark cycle whereas peripheral clocks occur in peripheral tissues and influenced by other environmental factors such as feeding. The rhythmic alterations in activities of metabolic pathways are provided by the coordinated expressions of clock genes and consequently by clock-controlled genes. The current studies indicate that consumption of food at inappropriate times as well as sleep restrictions lead to metabolic dysfunctions due to disruption of circadian rhythm which result in diabetes, obesity and heart diseases. To this end, it is aimed, in this review, to examine interactions among food or sleep, metabolism and circadian rhythm with an insight into metabolomic profiling studies of circadian disturbances by sleep restrictions following an overview of working mechanisms of circadian rhythms in mammals.en_US
dc.identifier.doi10.1080/09291016.2016.1251968
dc.identifier.endpage261en_US
dc.identifier.issn0929-1016
dc.identifier.issn1744-4179
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-84994885688en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage243en_US
dc.identifier.urihttps://doi.org/10.1080/09291016.2016.1251968
dc.identifier.urihttps://hdl.handle.net/11616/97578
dc.identifier.volume48en_US
dc.identifier.wosWOS:000396549200006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiological Rhythm Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCircadian clocksen_US
dc.subjectmetabolismen_US
dc.subjectnuclear receptorsen_US
dc.subjectsleep disordersen_US
dc.subjectchronobiology disordersen_US
dc.titleCircadian rhythm in mammals: time to eat & time to sleepen_US
dc.typeArticleen_US

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