Maternal viral mimetic administration at the beginning of fetal hypothalamic nuclei development accelerates puberty in female rat offspring

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dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authoridYildiz, Azibe/0000-0001-5686-7867
dc.authorwosidYILDIZ, SEDAT/AAB-6354-2021
dc.authorwosidVardı, Nigar/C-9549-2018
dc.authorwosidÖzgöçer, Tuba/AAA-1751-2021
dc.authorwosidYildiz, Azibe/ABI-7998-2020
dc.contributor.authorCakan, Pinar
dc.contributor.authorYildiz, Sedat
dc.contributor.authorOzgocer, Tuba
dc.contributor.authorYildiz, Azibe
dc.contributor.authorVardi, Nigar
dc.date.accessioned2024-08-04T20:44:28Z
dc.date.available2024-08-04T20:44:28Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThis study aimed to investigate the effects of maternal viral infection during a critical time window of fetal hypothalamic development on timing of puberty in the female offspring. For that purpose, a viral mimetic (i.e., synthetic double-strand RNA, namely, polyinosinic-polycytidylic acid, poly (I:C)) or saline was injected (i.p.) to the pregnant rats during the beginning (day 12 of pregnancy, n = 5 for each group) or at the end of this time window (day 14 of pregnancy, n = 5 for each group). Four study groups were formed from the female pups (n = 9-10 pups/group). Following weaning of pups, vaginal opening and vaginal smearing was studied daily until 2 sequential estrous cycles were observed. During the second diestrus phase, blood samples were taken for progesterone, leptin, corticosterone, follicle-stimulating hormone, and luteinizing hormone. Maternal poly (I:C) injection on day 12 of pregnancy increased body mass and reduced the time to puberty in the female offspring. Neither poly (I:C) nor timing of injection affected other parameters studied (p > 0.05). It has been shown for the first time that maternal viral infection during the beginning of fetal hypothalamic development might hasten puberty by increasing body mass in rat offspring.en_US
dc.description.sponsorshipInonu University, Scientific Research Projects [2012/41]en_US
dc.description.sponsorshipThis study was supported by Inonu University, Scientific Research Projects Unit (Project No. 2012/41).en_US
dc.identifier.doi10.1139/cjpp-2016-0535
dc.identifier.endpage514en_US
dc.identifier.issn0008-4212
dc.identifier.issn1205-7541
dc.identifier.issue5en_US
dc.identifier.pmid28825971en_US
dc.identifier.scopus2-s2.0-85046405472en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage506en_US
dc.identifier.urihttps://doi.org/10.1139/cjpp-2016-0535
dc.identifier.urihttps://hdl.handle.net/11616/98267
dc.identifier.volume96en_US
dc.identifier.wosWOS:000431480700008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCanadian Science Publishing, Nrc Research Pressen_US
dc.relation.ispartofCanadian Journal of Physiology and Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectviralen_US
dc.subjectpubertyen_US
dc.subjectpoly (I:C)en_US
dc.subjecthypothalamusen_US
dc.titleMaternal viral mimetic administration at the beginning of fetal hypothalamic nuclei development accelerates puberty in female rat offspringen_US
dc.typeArticleen_US

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