Drug induced autoimmune hepatitis: A single center experience

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dc.authorscopusid23979648200
dc.authorscopusid10144082400
dc.authorscopusid57214577978
dc.authorscopusid23018615700
dc.authorscopusid56582513000
dc.authorscopusid25959851900
dc.authorscopusid6506721526
dc.contributor.authorBilgic Y.
dc.contributor.authorHarputluoglu H.
dc.contributor.authorYilmaz C.
dc.contributor.authorKaradag N.
dc.contributor.authorCagin Y.F.
dc.contributor.authorAkbulut S.
dc.contributor.authorSeckin Y.
dc.date.accessioned2024-08-04T19:59:38Z
dc.date.available2024-08-04T19:59:38Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: Many drugs such as minocycline, nitrofurantoin, halothane, non-steroidal anti-inflammatory drugs, anti TNF (Tumor Necrosis Factor) antagonists can induce the autoimmune hepatitis. Herein, we aimed to assess patients suffering from drug induced autoimmune hepatitis who were hospitalized with acute hepatitis like transaminase elevations to our clinic between 2009-2015. Method: The patients were determined using simplified diagnostic criteria of the International Autoimmune Hepatitis Group. Results: We determined 9 patients whose score were compatible with the diagnosis of Autoimmune hepatitis (AIH). Three patients were older than 50, and six patients were between 19 and 31. Seven of nine patients were female. The drugs thought responsible for AIH were as follows; ciprofloxacin alone, amoxicillin plus nimesulid, amoxicillin plus ornidazole, amoxicillin alone, a combined oral contraceptive pill plus a mixture of natural drugs, metronidazole plus dexketoprofen, ramipril plus metronidazole, levofloxacin alone and venlafaxine plus mianserin for each case. Five of nine patients had been followed up conservatively upon discontinuation of drug(s) and did not need any treatment during hospitalization and resolved spontaneously. Four patients received immunosuppressive treatment which was withdrawn in 3 of those 4 patients after 3 to 6 months upon remission without relapse. Conclusion: Drug induced autoimmune hepatitis (DIAIH) can be presented with acute hepatitis of unknown etiology. Female sex seems to be a risk factor for DIAH. Treatment decisions should be given according to patient’s clinical status and follow up at acute presentations. There can be no treatment need, but, when needed generally a short course of immunosuppressive treatment can be sufficient. © 2017, Scientific Publishers of India. All Rights Reserved.en_US
dc.identifier.endpage6532en_US
dc.identifier.issn0970-938X
dc.identifier.issue15en_US
dc.identifier.scopus2-s2.0-85029601565en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage6528en_US
dc.identifier.urihttps://hdl.handle.net/11616/90772
dc.identifier.volume28en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherScientific Publishers of Indiaen_US
dc.relation.ispartofBiomedical Research (India)en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAutoimmunityen_US
dc.subjectDrugen_US
dc.subjectHepatitisen_US
dc.titleDrug induced autoimmune hepatitis: A single center experienceen_US
dc.typeArticleen_US

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