Is there a new pathway relationship between melatonin and FEZ1 in experimental rat model of Alzheimer's disease?

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dc.authoridCigremis, Yilmaz/0000-0002-8600-0946
dc.authoridSandal, Suleyman/0000-0002-8916-3329
dc.authoridÖzyalın, Fatma/0000-0001-6486-6389
dc.authoridYilmaz, Umit/0000-0003-0248-3483
dc.authoridDemir, Mehmet/0000-0001-6990-3337
dc.authoridözyalın, fatma/0000-0001-6486-6389
dc.authoridÇOLAK, CEMİL/0000-0001-5406-098X
dc.authorwosidCigremis, Yilmaz/O-6019-2015
dc.authorwosidSandal, Suleyman/AAA-6388-2021
dc.authorwosidÖzyalın, Fatma/ABC-7193-2020
dc.authorwosidYilmaz, Umit/JFA-5784-2023
dc.authorwosidCigremis, Yilmaz/JAC-8451-2023
dc.authorwosidDemir, Mehmet/HLV-7821-2023
dc.authorwosidözyalın, fatma/ABA-5258-2020
dc.contributor.authorDemir, M.
dc.contributor.authorYilmaz, U.
dc.contributor.authorColak, C.
dc.contributor.authorCigremis, Y.
dc.contributor.authorOzyalin, F.
dc.contributor.authorTekedereli, I
dc.contributor.authorSandal, S.
dc.date.accessioned2024-08-04T20:45:41Z
dc.date.available2024-08-04T20:45:41Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAlzheimer's disease (AD) is a progressive neurodegenerative disease. This study was performed to determine the possible relationship between melatonin, which is known to play a role in the neuro-protective mechanism in AD, and fasciculation and elongation protein zeta 1 (FEZ1). Thirty male rats were included and separated into 3 groups (n = 10) as vehicle (artificial cerebrospinal fluid), streptozotocin (STZ) and STZ+melatonin (MLT). Two intracerebroventricular (icv) injections of 3 mg/kg STZ were made 48 hours apart. MLT injections were implemented for 14 days (ip; 10mg/kg/day). The Morris Water Maze (MWM) test was performed and rats were sacrificed to assess FEZ1 gene expression and protein levels from the hippocampus tissues and serum levels of noradrenaline (NA), dopamine and serotonin were determined from the blood samples. It was determined that the FEZ1/beta-actin protein ratio in the STZ group was significantly higher than that of the Vehicle group (p < 0.05) and in the MLT-administered group, the protein levels were decreased to the levels observed in the Vehicle group. Serum NA levels of STZ and STZ+MLT groups were found to be lower than those in the Vehicle group, while no difference was found regarding dopamine and serotonin levels. These findings show that reversal of increased FEZ1 levels in AD-induced rats with melatonin administration is the evidence of the effect of melatonin through FEZ1 in AD (Tab. 2, Fig. 5, Ref. 67).en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [214S410]en_US
dc.description.sponsorshipThis study was supported by the Scientific and Technological Research Council of Turkey (TUBITAK) (Project No: 214S410).en_US
dc.identifier.doi10.4149/BLL_2019_011
dc.identifier.endpage77en_US
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue1en_US
dc.identifier.pmid30685996en_US
dc.identifier.scopus2-s2.0-85060656618en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage70en_US
dc.identifier.urihttps://doi.org/10.4149/BLL_2019_011
dc.identifier.urihttps://hdl.handle.net/11616/98627
dc.identifier.volume120en_US
dc.identifier.wosWOS:000457596700012en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherComenius Univen_US
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFEZ1en_US
dc.subjectAlzheimer's diseaseen_US
dc.subjectmelatoninen_US
dc.subjectraten_US
dc.subjectmicrotubulesen_US
dc.subjectmitochondriaen_US
dc.titleIs there a new pathway relationship between melatonin and FEZ1 in experimental rat model of Alzheimer's disease?en_US
dc.typeArticleen_US

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