The effect of hysteroscopic polypectomy on the gene expression of endometrial receptivity markers: HOXA10, HOXA11 and LIF

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dc.authorscopusid7006050141
dc.authorscopusid7004349870
dc.authorscopusid6507986599
dc.authorscopusid55377933500
dc.authorscopusid6506553159
dc.authorscopusid57197611783
dc.authorscopusid6506393120
dc.contributor.authorYildirim E.
dc.contributor.authorCelik O.
dc.contributor.authorAkgoz M.
dc.contributor.authorAksoy I.
dc.contributor.authorTürkan A.
dc.contributor.authorKaraca Z.M.
dc.contributor.authorCigremis Y.
dc.date.accessioned2024-08-04T20:02:27Z
dc.date.available2024-08-04T20:02:27Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of this study is to determine the effect of hysteroscopic polypectomy on the mRNA expression levels of the endometrial receptivity markers, namely, homeobox A10 (HOXA10), homeobox A11 (HOXA11) and leukemia inhibitory factor (LIF). Twenty-five reproductive-aged women with endometrial polyps underwent hysteroscopy. Samples were taken at the mid-secretory phase using hysteroscopic polypectomy and 4 months after polypectomy, and the change in mRNA expression levels of normalized HOXA10, HOXA11 and LIF genes were determined using Reverse Transcription Quantitative Real Time-Polymerase Chain Reaction (RT-qPCR). The results show that mRNA levels of HOXA10 and HOXA11 taken prior to surgery and 4 months after the complete hysteroscopic removal of polyps were not significantly different (P=0.79 and P=0.14, respectively). Moreover, a marked difference could not be obtained between preoperative and postoperative endometrial LIF mRNA expression levels (P=0.86). As a conclusion, these results indicate that mRNA levels of HOXA10, HOXA11 and LIF genes, three of molecular markers of endometrial receptivity, are not affected by hysteroscopic polypectomy.en_US
dc.identifier.endpage104en_US
dc.identifier.issn1529-9120
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-84904556152en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage95en_US
dc.identifier.urihttps://hdl.handle.net/11616/91705
dc.identifier.volume16en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherGene Therapy and Molecular Biologyen_US
dc.relation.ispartofGene Therapy and Molecular Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEndometrialpolypen_US
dc.subjectHomeobox A10en_US
dc.subjectHomeobox A11en_US
dc.subjectHoxa10en_US
dc.subjectHOXA11 and LIFen_US
dc.subjectRT-qPCRen_US
dc.titleThe effect of hysteroscopic polypectomy on the gene expression of endometrial receptivity markers: HOXA10, HOXA11 and LIFen_US
dc.typeArticleen_US

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