Decision-making and impulse-control disorders in Parkinson's disease: Influence of dopaminergic treatment

Basit Öğe Kaydı
dc.authoridYıldırım, Elif/0000-0003-3445-9197
dc.authorwosidYıldırım, Elif/C-1965-2017
dc.contributor.authorYildirim, Elif
dc.contributor.authorAltinayar, Sibel
dc.contributor.authorCakmur, Raif
dc.date.accessioned2024-08-04T20:47:17Z
dc.date.available2024-08-04T20:47:17Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: Dopaminergic treatment is proved to ameliorate motor deficits in Parkinson's disease (PD); however, it could have negative effects on behavior and cognition, including impulse controlling and decision-making. We aimed (1) to investigate the decision-making and impulse-control disorders (ICDs) of PD patients and their correlations with sociodemographical and clinical variables, dopaminergic treatment in particular, and (2) to determine the relation of decision-making with ICDs. Methods: The sample of 39 patients with PD and 37 healthy controls underwent cognitive tests and the task which analyzed decision-making (Iowa Gambling Task [IGT]). Besides assessing motor and nonmotor symptoms of patients with PD, ICDs were also scanned using the Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease. Results: Although patients with PD performed similarly to healthy controls on IGT, decision-making profile in PD related to clinical variables: dopaminergic treatment and duration of illness. In addition to this younger age of onset, higher dose of dopamine agonists, longer duration of illness, and impaired decision-making were together accounted for a substantial amount of variance in impulsive behaviors. Conclusions: Dopaminergic medication likely contributes to the impairment in decision-making, which may be the underlying mechanism of ICDs. Further studies will be necessary to understand the potential implications of this finding.en_US
dc.identifier.doi10.4103/NSN.NSN_12_20
dc.identifier.endpage17en_US
dc.identifier.issn2636-865X
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85084739668en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage11en_US
dc.identifier.urihttps://doi.org/10.4103/NSN.NSN_12_20
dc.identifier.urihttps://hdl.handle.net/11616/99283
dc.identifier.volume37en_US
dc.identifier.wosWOS:000538041000003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofNeurological Sciences and Neurophysiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDecision-makingen_US
dc.subjectdopamineen_US
dc.subjectimpulse-control disordersen_US
dc.subjectParkinson's diseaseen_US
dc.titleDecision-making and impulse-control disorders in Parkinson's disease: Influence of dopaminergic treatmenten_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu