Evaluation of autonomic activity in patients with subclinical hypothyroidism

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dc.authoridGunen, Hakan/0000-0001-6631-4457
dc.authoridSahin, Ibrahim/0000-0002-6231-0034
dc.authoridTaskapan, Mehmet Cagatay/0000-0002-5273-4909
dc.authorwosidŞahin, İbrahim/HHY-8303-2022
dc.authorwosidGunen, Hakan/HKV-9202-2023
dc.authorwosidturan, nedim/GXG-8035-2022
dc.authorwosidSahin, Ibrahim/ABI-6050-2020
dc.authorwosidTaskapan, Mehmet Cagatay/ABI-7747-2020
dc.contributor.authorSahin, I
dc.contributor.authorTuran, N
dc.contributor.authorKosar, F
dc.contributor.authorTaskapan, C
dc.contributor.authorGunen, H
dc.date.accessioned2024-08-04T20:14:49Z
dc.date.available2024-08-04T20:14:49Z
dc.date.issued2005
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIt has been shown that impaired cardiac autonomic activity is closely related with lethal arhythmias. Heart rate variability (HRV), analysis of beat-to-beat variations, is an important and widely used non-invasive method to assess autonomic function. Impaired cardiac autonomic activity and altered sympathovagal balance were previously documented in patients with hypothyroidism. However, the effect of subclinical hypothyroidism (SH) on autonomic function has not been studied yet. We aimed to investigate the effect of SH on sympathovagal balance using the HRV method. The study included 31 patients with SH and 28 healthy volunteer controls. Patients with cardiac, metabolic, neurological disease or any other systemic disease that could affect autonomic activity were excluded from the study. HRV time domain and frequency domain parameters were determined over a period 24 h. All time and frequency domain measures of HRV in patients with SH were not significantly different compared to those of healthy control group (p > 0.05). Additionally, we compared SH subgroups (TSH level >= 10 and TSH level < 10 mU/l) with each other and the controls. A statistically significant difference was observed only in time domain parameters of SD of normal-to-normal intervals (SDNN) and SD of all 5-min mean normal NN intervals (SDANN) between subgroup with TSH level >= 10 and controls (p < 0.05, p < 0.05, respectively). In correlation analysis with TSH, there was positive relationship between TSH and the root mean square of successive differences between adjacent R-R intervals (rMSSD). These findings indicate that SH may affect cardiac autonomic activity in correlation with TSH levels. (c) 2005, Editrice Kurtis.en_US
dc.identifier.doi10.1007/BF03345374
dc.identifier.endpage213en_US
dc.identifier.issn0391-4097
dc.identifier.issn1720-8386
dc.identifier.issue3en_US
dc.identifier.pmid15952403en_US
dc.identifier.scopus2-s2.0-21444447027en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage209en_US
dc.identifier.urihttps://doi.org/10.1007/BF03345374
dc.identifier.urihttps://hdl.handle.net/11616/93988
dc.identifier.volume28en_US
dc.identifier.wosWOS:000229053500003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Endocrinological Investigationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectsubclinic hypothyroidismen_US
dc.subjectcardiac autonomic activityen_US
dc.subjectheart rate variabilityen_US
dc.titleEvaluation of autonomic activity in patients with subclinical hypothyroidismen_US
dc.typeArticleen_US

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