Comparison of ganglion cell and retinal nerve fiber layer thickness in primary open-angle glaucoma and normal tension glaucoma with spectral-domain OCT

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dc.authoridÇOLAK, CEMİL/0000-0001-5406-098X
dc.authoridBozgul, Pembegul/0000-0002-9427-3610
dc.authorwosidÇOLAK, CEMİL/ABI-3261-2020
dc.authorwosidBozgul, Pembegul/AAQ-4951-2020
dc.contributor.authorFirat, Penpe Gul
dc.contributor.authorDoganay, Selim
dc.contributor.authorDemirel, Ersan Ersin
dc.contributor.authorColak, Cemil
dc.date.accessioned2024-08-04T20:37:32Z
dc.date.available2024-08-04T20:37:32Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of this study was to evaluate the macular thickness (MT), ganglion cell complex (GCC), and circum-papillary retinal nerve fiber layer (RNFL) thickness in primary open-angle glaucoma (POAG) and normal tension glaucoma (NTG) with spectral domain optical coherence tomography (SD-OCT). A total of 169 subjects were enrolled: 52 normal subjects, 61 with POAG, and 56 with NTG. Spectral-domain optical coherence tomography (SD-OCT) was used to analyze MT, GCC, and RNFL thickness. To compare the discrimination capabilities between the MT, GCC, and RNFL thickness measurements, we analyzed the areas under the receiver operating characteristic (ROC) curves (AUCs). The relationships between GCC and RNFL measurement and also the relationships of the groups, with age, gender, GCC, and RNFL thickness were assessed. Normal subjects showed the thickest superior and inferior GCC, followed by in order NTG and POAG (p < 0.05). While there was a statistically difference in MT value of the normal subjects and the glaucoma patients (p < 0.05), MT value did not differ between POAG and NTG (p < 0.05). RNFL thickness parameters were significantly greater in normal subjects, followed in order by the NTG, and POAG (p < 0.05). Between the normal and entire glaucoma groups, all GCC and RNFL parameters showed the similar discrimination power. RNFL thickness parameters correlated significantly with all GCC thickness (p < 0.05). Superior RNFL thickness was the only independent variable between the POAG and NTG patients (odds ratio (OR) 0.942, p = 0.004, 95 %CI 0.905-0.981). SD-OCT evaluation results suggest higher GCC and RNFL parameters for NTG than POAG.en_US
dc.identifier.doi10.1007/s00417-012-2114-5
dc.identifier.endpage838en_US
dc.identifier.issn0721-832X
dc.identifier.issue3en_US
dc.identifier.pmid22903819en_US
dc.identifier.scopus2-s2.0-84876284474en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage831en_US
dc.identifier.urihttps://doi.org/10.1007/s00417-012-2114-5
dc.identifier.urihttps://hdl.handle.net/11616/96007
dc.identifier.volume251en_US
dc.identifier.wosWOS:000315418000027en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofGraefes Archive For Clinical and Experimental Ophthalmologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPrimary open-angle glaucomaen_US
dc.subjectNormal tension glaucomaen_US
dc.subjectGanglion cell complexen_US
dc.subjectRetinal nerve fiber layer thicknessen_US
dc.subjectSpectral optical coherence tomographyen_US
dc.titleComparison of ganglion cell and retinal nerve fiber layer thickness in primary open-angle glaucoma and normal tension glaucoma with spectral-domain OCTen_US
dc.typeArticleen_US

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