Caffeic acid phenethyl ester ameliorated ototoxicity induced by cisplatin in rats

Basit Öğe Kaydı
dc.authoridKIZILAY, Ahmet/0000-0003-3048-6489
dc.authoridOZTURAN, ORHAN/0000-0002-6129-8627
dc.authorwosidÖZEROL, ELİF/AAA-6707-2021
dc.authorwosidKIZILAY, Ahmet/ABI-8293-2020
dc.authorwosidKalcioglu, M. Tayyar/JAC-1515-2023
dc.authorwosidKALCIOGLU, Mahmut Tayyar/I-5884-2013
dc.authorwosidOZTURAN, ORHAN/E-9610-2012
dc.authorwosidOZTURAN, ORHAN/B-4984-2015
dc.contributor.authorKizilay, A
dc.contributor.authorKalcioglu, MT
dc.contributor.authorOzerol, E
dc.contributor.authorIraz, M
dc.contributor.authorGulec, M
dc.contributor.authorAkyol, O
dc.contributor.authorOzturan, O
dc.date.accessioned2024-08-04T20:30:41Z
dc.date.available2024-08-04T20:30:41Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractCaffeic acid phenethyl ester (CAPE), an active component of propolis, exhibits antioxidant properties. This experimental study was designed to determine the effect of CAPE on ototoxicity induced with cisplatin. Twenty-four adult Wistar albino rats were divided into four groups: cisplatin (n=6), saline (n=6), CAPE (n=6), and cisplatin plus CAPE (n=6). Rats were tested before and 5 days after cisplatin treatment with or without chemo protection. The Distortion Product Otoacoustic Emissions (DPOAEs) were elicited from the control and experimental animals utilizing the standard commercial Otoacoustic Emission (OAEs) apparatus. The animals in all groups were sacrificed under general anesthesia on the fifth day following last OAE measurements. For biochemical investigations, the blood samples were drawn from inferior vena cava. On day 0, the initial baseline DPOAEs measurement results presented similar values while comparing the groups in drug free phase (p>0.05). On day 5, intrasubject measurement parameters of DPgrams and I/O functions of cisplatin group were significantly deteriorated (p<0.05). The second measurements of the other groups revealed no significant differences between their DPgrams and I/O functions in all frequencies (p>0.05). Among the biochemical parameters, plasma xanthine oxidase (XO) activity was found to be more elevated in the cisplatin group than the saline group (p<0.05). CAPE led to more decreased XO activity than cisplatin (p<0.05). The results of this study show that prophylactic administration of CAPE for cisplatin ototoxicity ameliorated hearing deterioration in rats.en_US
dc.identifier.doi10.1179/joc.2004.16.4.381
dc.identifier.endpage387en_US
dc.identifier.issn1120-009X
dc.identifier.issue4en_US
dc.identifier.pmid15332714en_US
dc.identifier.scopus2-s2.0-3943076441en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage381en_US
dc.identifier.urihttps://doi.org/10.1179/joc.2004.16.4.381
dc.identifier.urihttps://hdl.handle.net/11616/94458
dc.identifier.volume16en_US
dc.identifier.wosWOS:000223141700011en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherE I F T Srlen_US
dc.relation.ispartofJournal of Chemotherapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectototoxicityen_US
dc.subjectcisplatinen_US
dc.subjectantioxidant agentsen_US
dc.subjectcaffeic acid phenethyl esteren_US
dc.subjectotoacoustic emissionsen_US
dc.subjectouter hair cellsen_US
dc.subjectraten_US
dc.titleCaffeic acid phenethyl ester ameliorated ototoxicity induced by cisplatin in ratsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu