Biodegradable non-aromatic adhesive polyurethanes based on disaccharides for medical applications

dc.authoridBALCIOGLU, Sevgi/0000-0003-0724-4772
dc.authoridBALCIOGLU, Sevgi/0000-0003-0724-4772
dc.authoridAteş, Burhan/0000-0001-6080-229X
dc.authoridKoytepe, Suleyman/0000-0002-4788-278X
dc.authoridKARAASLAN, MERVE GOKSIN/0000-0003-2645-808X
dc.authorwosidKöytepe, Süleyman/AAA-4168-2021
dc.authorwosidBALCIOGLU, Sevgi/O-3576-2015
dc.authorwosidBALCIOGLU, Sevgi/W-5874-2018
dc.authorwosidAteş, Burhan/AAA-3730-2021
dc.contributor.authorAtes, Burhan
dc.contributor.authorKoytepe, Suleyman
dc.contributor.authorKaraaslan, Merve Goksin
dc.contributor.authorBalcioglu, Sevgi
dc.contributor.authorGulgen, Selam
dc.date.accessioned2024-08-04T20:38:01Z
dc.date.available2024-08-04T20:38:01Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThis work addresses synthesis, characterization, adhesive properties, protein adsorption and in vitro biodegradation of non-aromatic polyurethanes (NPUs). The following reactants were used in the syntheses of polyurethanes (PUs): non-aromatic 4,4'-Methylenebis(cyclohexyl isocyanate) (MCI), disaccharides (maltose and sucrose) and polyethylene glycol 200 (PEG 200). The NPUs exhibited low glass transition temperature (T-g) and good thermal stability. The dynamic contact angles on NPUs were influenced by the ratios of PEG 200-disaccharide monomer and the hard segment of the NPUs. The highest adhesion strength in whole polyurethanes was found as 307.6 +/- 50.1 kPa for 15% sucrose containing polyurethane. Protein adsorptions of polyurethane films were measured as average 10 pg Bovine Serum Albumin (BSA)/cm(2) and 5 mu g fibrinogen/cm(2) for maltose, and 15 mu g BSA/cm(2) and 5 mu g fibrinogen/cm(2) for sucrose. Biodegradability ratios of NPUs were in the range of 15-35% for 8 weeks depending on the disaccharides containing NPUs. (C) 2013 Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipScientific and Technical Research Council of Turkey (TUBITAK) [TBAG-(111T104)]en_US
dc.description.sponsorshipThis study was supported by a grant (TBAG-(111T104)) to B. Ates from The Scientific and Technical Research Council of Turkey (TUBITAK).en_US
dc.identifier.doi10.1016/j.ijadhadh.2013.12.012
dc.identifier.endpage96en_US
dc.identifier.issn0143-7496
dc.identifier.issn1879-0127
dc.identifier.scopus2-s2.0-84891686597en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage90en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijadhadh.2013.12.012
dc.identifier.urihttps://hdl.handle.net/11616/96314
dc.identifier.volume49en_US
dc.identifier.wosWOS:000332141700013en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofInternational Journal of Adhesion and Adhesivesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPolyurethaneen_US
dc.subjectNovel adhesivesen_US
dc.subjectBioadhesiveen_US
dc.titleBiodegradable non-aromatic adhesive polyurethanes based on disaccharides for medical applicationsen_US
dc.typeArticleen_US

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