Synthesis, reaction, and evaluation of the anticancer activity of6,7,8,9-tetrahydro-5H-cyclohepta[4,5]selenopheno[2,3-d]pyrimidine derivatives
| dc.contributor.author | Doğanay, Kadir | |
| dc.contributor.author | Keleştemur, Unzile | |
| dc.contributor.author | Balcıoğlu, Sevgi | |
| dc.contributor.author | Ateş, Burhan | |
| dc.contributor.author | Altundaş, Aliye | |
| dc.date.accessioned | 2020-11-10T12:37:45Z | |
| dc.date.available | 2020-11-10T12:37:45Z | |
| dc.date.issued | 2016 | |
| dc.department | İnönü Üniversitesi | en_US |
| dc.description.abstract | Abstract: The cyclocondensation of 2-amino-5,6,7,8-tetrahydro-4H-cyclohepta[b] selenophene-3-carbonitrile (1) withformic acid and formamide gave the selenophenopyrimidine15and selenophenopyrimidone6derivatives. The reactionof6with phosphorus oxychloride produced 4-chloro-6,7,8,9-tetrahydro-5H-cyclohepta[4,5] seleno[2,3-d]pyrimidine (12),the key compound for our nucleophilic substitution reactions. The hydrazinoselenophenopyrimidine19obtained from thereaction of12with hydrazine hydrate was converted to its tetrazoloselenophenopyrimidine21and triazoloselenophenopy-rimidine26derivatives. Moreover, the chloropyrimidine derivative was reacted with pyrrolidine and morpholine to afford4-(1-pyrrolidinyl)-6,7,8,9-tetrahydro-5H-cylohepta[4,5]selenopheno[2,3-d]pyrimidine (27) and 4-(6,7,8,9-tetrahydro-5H-cyclohepta[4,5]selenopheno[2,3-d]pirimidin-4-yl)morpholine (28). Anticancer activities of the synthesized compoundswere investigated against the MCF-7 breast cancer cell line and the IC50values of these compounds were in the rangeof 70.86{250.06M. | en_US |
| dc.identifier.citation | DOĞANAY K,KELEŞTEMUR U,BALCIOĞLU S,ATEŞ B,ALTUNDAŞ A (2016). Synthesis, reaction, and evaluation of the anticancer activity of6,7,8,9-tetrahydro-5H-cyclohepta[4,5]selenopheno[2,3-d]pyrimidine derivatives. Turkish Journal of Chemistry, 40(4), 631 - 640. | en_US |
| dc.identifier.endpage | 640 | en_US |
| dc.identifier.issn | 1300-0527 | |
| dc.identifier.issn | 1303-6130 | |
| dc.identifier.issue | 4 | en_US |
| dc.identifier.startpage | 631 | en_US |
| dc.identifier.trdizinid | 256125 | en_US |
| dc.identifier.uri | https://hdl.handle.net/11616/18713 | |
| dc.identifier.uri | https://search.trdizin.gov.tr/yayin/detay/256125 | |
| dc.identifier.volume | 40 | en_US |
| dc.indekslendigikaynak | TR-Dizin | en_US |
| dc.language.iso | tr | en_US |
| dc.publisher | Turkish Journal of Chemistry | en_US |
| dc.relation.ispartof | Turkish Journal of Chemistry | en_US |
| dc.relation.publicationcategory | Makale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.title | Synthesis, reaction, and evaluation of the anticancer activity of6,7,8,9-tetrahydro-5H-cyclohepta[4,5]selenopheno[2,3-d]pyrimidine derivatives | en_US |
| dc.type | Article | en_US |
